Publications by authors named "Angela K Mayes"

Aim: The neurobiological contributions of childhood language disorder are not well understood. Yet there is increasing evidence that language disorder is associated with differences in brain structure and/or function in core language regions. A key hypothesis has been that children with language disorder do not show the same degree of leftward asymmetry of these regions as observed in typically developing children.

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Objective: To delineate the specific speech deficits in individuals with epilepsy-aphasia syndromes associated with mutations in the glutamate receptor subunit gene GRIN2A.

Methods: We analyzed the speech phenotype associated with GRIN2A mutations in 11 individuals, aged 16 to 64 years, from 3 families. Standardized clinical speech assessments and perceptual analyses of conversational samples were conducted.

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Article Synopsis
  • * Nineteen schizophrenia patients were compared to seventeen control subjects, revealing significant deficits in emotion recognition for patients during both static and dynamic tasks.
  • * The findings suggest that negative symptoms correlate with poor recognition of static emotions, while positive symptoms relate to difficulties with dynamic emotions, indicating different underlying neural mechanisms for processing these types of facial expressions.
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