First in-human evaluation of [1-C]pyruvate in DO for hyperpolarized MRI of the brain: A safety and feasibility study.

Purpose: To investigate the safety and value of hyperpolarized (HP) MRI of [1-C]pyruvate in healthy volunteers using deuterium oxide (DO) as a solvent.

Methods: Healthy volunteers (n = 5), were injected with HP [1-C]pyruvate dissolved in DO and imaged with a metabolite-specific 3D dual-echo dynamic EPI sequence at 3T at one site (Site 1). Volunteers were monitored following the procedure to assess safety.