Publications by authors named "Angela Gomez-Mediavilla"
Adipose tissue has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in many metabolic tissues. With this regard, emerging evidence indicates that an important crosstalk exists between the adipose tissue and the brain. However, the contribution of adipose tissue to the development of age-related diseases, including Alzheimer's disease, remains poorly defined.
View Article and Find Full Text PDFPlasmablastic lymphoma mutational profile is undescribed. Here we performed a targeted exonic NGS analysis of 30 plasmablastic lymphoma cases with a B cell lymphoma dedicated panel and FISH for the detection of MYC rearrangements. A complete phenotyping of the neoplastic and microenvironment cell populations was also performed.
View Article and Find Full Text PDFDiagnostic value of bone marrow core biopsy patterns in lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia and description of its mutational profiles by targeted NGS.
J Clin Pathol
September 2020
Article Synopsis
- * Researchers reviewed 35 bone marrow biopsies from 28 patients, employing various methods such as morphology analysis, immunohistochemistry, and next-generation sequencing (NGS) to find mutations related to lymphoma.
- * Results indicated that bone marrow trephine biopsy is more effective than flow cytometry for detecting lymphoid infiltrates, with specific infiltration patterns observed in LPL/WM and IgM-MGUS cases; mutations other than p.L265P were also identified in a subset of cases.