Publications by authors named "Angela F Britton"
Article Synopsis
- Central obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), is linked to body fat distribution, with a focus on minority populations, particularly those of African ancestry.
- Genome-wide association studies (GWAS) were conducted on over 33,000 AA individuals, identifying 25 SNPs that were analyzed further, with two SNPs showing strong associations with WC and WHR after adjustments for BMI, though neither reached genome-wide significance.
- The study also confirmed six previously identified fat distribution loci from European ancestry populations and suggested potential sexual dimorphism in associations, especially among AA women at the GRB14 locus.
Rationale: Individuals vary in their susceptibility to nicotine addiction. However, there is little evidence that behavioral sensitivity to nicotine is dependent upon the functional state of nicotinic cholinergic receptors (nAChRs).
Objective: This study aims to determine the relationship between in vivo behavioral desensitization and in vitro desensitization of nAChR function.
Maternal smoking is a risk factor associated with nicotine abuse, so the effect of perinatal nicotine exposure was studied on the responsiveness to nicotine across adolescence in the rat. Pregnant Sprague-Dawley rats were implanted with s.c.
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