Publications by authors named "Angela Cho"

Article Synopsis
  • The genus Streptococcus includes both harmless and harmful bacteria that naturally reside in the human body, particularly in the female genital tract (FGT), where there are two main groups: the pathogenic group B Streptococci (GBS) and the commensal viridans group streptococci (VGS).
  • A novel strain named Streptococcus sp. K0074 was isolated from a vaginal swab of an endometrial cancer patient and showed potential as a commensal member of the VGS, specifically within the mitis subgroup.
  • This strain produced a bacteriocin-like substance that can inhibit the growth and biofilm formation of the harmful bacterium MRSA, suggesting it may play a significant
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Brain cancer is a devastating and life-changing disease. Biomarkers are becoming increasingly important in addressing clinical issues, including in monitoring tumour progression and assessing survival and treatment response. The goal of this study was to identify prognostic biomarkers associated with glioma progression.

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Article Synopsis
  • The study evaluated long-term outcomes and recurrence risk factors in patients with cervical intraepithelial neoplasia (CIN) who underwent loop electrosurgical excision procedure (LEEP) from 2011 to 2019.
  • Out of 385 patients, 13.5% experienced treatment failure, with positive surgical margins and HPV detection being significant risk factors.
  • In terms of obstetric outcomes, the timing of delivery after LEEP was linked to preterm complications, with a history of preterm birth being a notable predictor of preterm delivery.
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In the 2023 series, we summarized the major clinical research advances in gynecologic oncology based on communications at the conference of Asian Society of Gynecologic Oncology Review Course. The review consisted of 1) Endometrial cancer: immune checkpoint inhibitor, antibody drug conjugates (ADCs), selective inhibitor of nuclear export, CDK4/6 inhibitors WEE1 inhibitor, poly (ADP-ribose) polymerase (PARP) inhibitors. 2) Cervical cancer: surgery in low-risk early-stage cervical cancer, therapy for locally advanced stage and advanced, metastatic, or recurrent setting; and 3) Ovarian cancer: immunotherapy, triplet therapies using immune checkpoint inhibitors along with antiangiogenic agents and PARP inhibitors, and ADCs.

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Deep endometriosis (DE) is endometriotic tissue that invades the peritoneum by >5 mm. Surgery is the treatment of choice for symptomatic DE, and laparoscopic surgery is preferred over laparotomy due to better vision and postoperative pain. In this review, we aimed to collect and summarize recent literature on DE surgery and share laparoscopic procedures for rectovaginal and bowel endometriosis.

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Article Synopsis
  • The study focuses on Extramammary Paget's disease (EMPD) of the vulva, specifically examining its clinical features in Korean women, as there are no previous studies on this demographic.
  • A total of 47 patients were analyzed, revealing that 21.3% experienced postoperative complications, mainly wound dehiscence, while 14.9% had disease recurrence, typically after a median of 69 months.
  • The research identified vulvar lesions larger than 40 mm as a significant risk factor for complications, but found no correlation between surgical margin status and recurrence, indicating the need for long-term surveillance beyond 5 years.
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Colposcopy is a test performed to detect precancerous lesions of cervical cancer. Since cervical cancer progresses slowly, finding and treating precancerous lesions helps prevent cervical cancer. In particular, it is clinically important to detect high-grade squamous intraepithelial lesions (HSIL) that require surgical treatment among precancerous lesions of cervix.

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Introduction And Importance: Carbohydrate antigen 19-9 (CA 19-9) can be increased in benign ovarian cysts, but extreme elevation is rare.

Case Presentation: We present a case of a mature cystic teratoma with extremely elevated CA 19-9 levels. After ovarian cystectomy, the level of CA 19-9 was decreased.

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Purpose: The primary objective of our study was to investigate the effectiveness and safety of olaparib maintenance therapy in patients with BRCA-mutated recurrent ovarian cancer in daily practice. The secondary objective of this study was to identify prognostic factors associated with prolonged progression-free survival (PFS) in such patients.

Methods: We conducted a retrospective analysis of 40 patients who received olaparib maintenance treatment.

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Despite having revolutionized the management of multiple types of gynecologic cancers laparoscopy and robotic surgery have had limited utility in ovarian cancer until recently. The development in medical technology allows surgeons to perform minimally invasive surgery (MIS) not only in early ovarian cancer, but also in advanced ovarian cancer. Thus far, most prospective studies showed feasible results of MIS in ovarian cancer.

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: Antenatal Bartter syndrome is an autosomal recessive disorder causing severe polyuria that leads to severe polyhydramnios and preterm labor. Prenatal diagnosis of antenatal Bartter syndrome is difficult because the genetic diagnosis can only be confirmed following a clinical diagnosis in infants. Reports of prenatal diagnosis and treatment of antenatal Bartter syndrome are limited.

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Objective: We aimed to investigate the effectiveness of continuing medical therapy in patients who did not achieve complete response (CR) despite 9 months of progestin treatment. We also sought to determine the prognostic factors associated with achieving CR among these patients.

Methods: We retrospectively analyzed 51 patients with presumed stage IA, grade 1 or 2 endometrioid adenocarcinoma who had persistent disease on biopsy performed at 9-12 months after at least 9 months of progestin-based therapy.

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Loop electrosurgical excision procedure (LEEP) is commonly performed for the management of cervical intraepithelial neoplasia. Although LEEP is considered to be a relatively simple procedure, several unexpected complications have been reported in the literature. Herein, we report a case of hemoperitoneum caused by uterine perforation following LEEP.

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Public health genomics has evolved to responsibly integrate advancements in genomics into the fields of personalized medicine and public health. Appropriate, effective and sustainable integration of genomics into healthcare requires an organized approach. This paper outlines the history that led to the emergence of public health genomics as a distinguishable field.

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Inflammation and coagulation are two intertwined pathways with evolutionary ties being traced back to the hemocyte, a single cell type in invertebrates that has functions in both the inflammatory and coagulation pathways. These systems have functioned together throughout evolution to provide a solid defence against infection, damaged cells and irritants. While these systems work in harmony the majority of the time, they can also become dysregulated or corrupted by tumours, enhancing tumour proliferation, invasion, dissemination and survival.

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Epithelial ovarian cancer is the fifth leading cause of cancer-related deaths in women and the most lethal gynecological malignancy. Extracellular matrix (ECM) is an integral component of both the normal and tumor microenvironment. ECM composition varies between tissues and is crucial for maintaining normal function and homeostasis.

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Purpose: Transforming growth factor beta-induced protein (TGFBIp) aggregates into the phenotypic amyloid fibrils and/or non-amyloid deposits in corneal dystrophies and other disorders. While significant progress has been made in molecular genetics to successfully establish the link between the missense mutations of TGFBI and TGFBIp-related corneal dystrophies, the underlying mechanism for the abnormal aggregation remains elusive due to the lack of insights into the conformational perturbations induced by mutations. In the present study, we examined the effects of denaturants and a co-solvent on recombinant TGFBIp, with a focus on protein conformational changes and amyloid fibril formation.

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A newly synthesized diethylene glycol functionalized chlorin-type photosensitizer, lemuteporfin, was characterized for use in photodynamic therapy (PDT) in a panel of in vitro and in vivo test systems. The photosensitizer was highly potent, killing cells at low nanomolar concentrations upon exposure to activating light. The cellular uptake of lemuteporfin was rapid, with maximum levels reached within 20 min.

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Synopsis of recent research by authors named "Angela Cho"

  • - Angela Cho's recent research primarily focuses on gynecologic oncology, exploring various aspects of cancer treatment, prognosis, and surgical techniques, particularly in the context of cervical and ovarian cancers.
  • - Findings from her studies highlight the importance of identifying prognostic biomarkers for glioma progression, evaluating long-term outcomes from surgical procedures for cervical intraepithelial neoplasia, and discussing the advancements in treatment for endometrial cancer.
  • - Cho's work also emphasizes the role of minimally invasive surgery in improving patient outcomes for deep endometriosis and ovarian cancer, while addressing unique cases and complications related to gynecological diseases.

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