Publications by authors named "Angel David Osorio-Pena"
Objective: To describe the results from the Global Burden Disease (GBD) study 2019 on the burden of other musculoskeletal (MSK) disorders in Latin America and the Caribbean (LAC).
Methods: In this cross-sectional study, we analyzed data from all LAC region in the GBD study from 1990 to 2019. Other MSK (other than rheumatoid arthritis, osteoarthritis, gout, low back pain, and neck pain) burden was measured as prevalence, mortality, years lived with disability (YLD), and disability-adjusted life (DALY), by year, sex, and country.
Article Synopsis
- This study investigated the trends and disease burden of musculoskeletal (MSK) disorders in Mexico from 1990 to 2019, using data from the Global Burden of Disease Study 2019.
- In 2019, there were approximately 4.8 million new cases of MSK disorders and the condition became the leading cause of years lived with disability (YLD) in Mexico, showing a significant increase over the years.
- The rise in MSK disorders is linked to risk factors like poor occupational ergonomics and high body mass index (BMI), indicating a need for better assessment and management strategies.
Article Synopsis
- * In a study of 110 SLE patients over 8 years, 50.1% achieved LDAS, leading to significantly lower incident VF rates, with adjusted analyses confirming the protective effect of LDAS on fracture risk.
- * However, achieving LDAS did not show a significant correlation with changes in bone mineral density (BMD), indicating that while LDAS helps reduce fracture risk, it may not improve bone density itself.
The aims of this study were in systemic lupus erythematosus (SLE) patients: 1) to compare the metabolomic profile of insulin resistance (IR) with controls and 2) to correlate the metabolomic profile with other IR surrogates and SLE disease variables and vitamin levels. In this cross-sectional study, serum samples were collected from women with SLE (n=64) and gender- and age-matched controls (n=71), which were not diabetic. Serum metabolomic profiling was performed using UPLC-MS-MS (Quantse score).
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- This systematic review evaluated the adherence of machine learning (ML) applications in diagnosing and predicting systemic lupus erythematosus (SLE) using the TRIPOD reporting guidelines.
- Out of 45 analyzed studies, only 17% to 67% of required reporting standards were met, with notable gaps in essential areas like model performance, blinding of predictors, and handling missing data.
- The overall conclusion suggests that current reporting practices for ML-based models in SLE are inadequate, highlighting the need for improved transparency and consistency in research reporting.
Article Synopsis
- Hospitalizations for systemic lupus erythematosus (SLE) in Mexico from 2000 to 2019 totaled 17,081, predominantly affecting females (87.6%) and individuals aged 15-44 years (87%).
- The age-standardized hospitalization rate increased from 0.38 to 0.65 per 100,000 persons from 2000 to 2019, with a notable rise until 2011, followed by a decline from 2011 to 2019.
- Despite the overall increase, the length of hospital stays and inpatient mortality rates decreased from 2000 to 2019, indicating improvements in patient care.
Objective: To investigate national temporal trends over time in mortality rates in patients with systemic sclerosis (SSc) in Mexico between 1998 and 2017.
Methods: Deaths between 1998 and 2017 were extracted from General Board of Health Information (DGIS) Open Access datasets. 2We identified all persons aged ≥15 years with a diagnosis of SSc (ICD-10 code M34).
Systemic lupus erythematosus (SLE) is one of the leading causes of death in younger adults, but advances in diagnosis and management during recent years may have reduced mortality. We examined whether SLE is a leading cause of death in Mexico among females. Data for death counts for the female population were obtained from the General Board of Health Information (DGIS) Open Access datasets, which evaluate death certificates, from 2000 to 2020.
View Article and Find Full Text PDFObjective: Regional variations in systemic lupus erythematosus (SLE) mortality may be due to different spectra of local environmental factors. The aim of this study was to assess mortality trends in adults with SLE using a nationwide health registry.
Methods: Data came from the Dynamic Cubes of the General Direction of Health Information for 1998-2017 for mortality.
is a gram-negative bacterium that adapts to the gastric mucosa and provokes symptoms associated with gastritis. Chronic infection in patients with a genetic predisposition can trigger autoimmune diseases due to the immune interaction of cellular and humoral responses. Infections are a triggering factor for systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjögren syndrome (SS), although the association between and these diseases is unclear.
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