Nat Prod Res
November 2022
Pentacyclic triterpenes are found in a great variety of natural products and constitute an organic template for the development of new derivative compounds with therapeutic applications. In the present work, lupeol acetate isolated from L. fruit was used as a template for the synthesis of novel -alkyl-arylsulfonamide derivatives, and their synergistic effects with metronidazole against strains of were tested.
View Article and Find Full Text PDFA series of 15 novel 1,3-thiazole amide derivatives of the pentacyclic triterpene Ochraceolide A () was synthesized, characterized, and evaluated against three human cancer cell lines (MCF-7, MDA-MB-231 and SiHa) and a normal cell line (Vero). Synthetic derivatives were obtained by acylation of the 2-aminothiazole triterpene , previously reported. Remarkably, the 5-nitrofuramide derivative () showed better cytotoxic and antiproliferative activity than compound and the other derivatives against the three cancer cell lines with CC and IC values of 1.
View Article and Find Full Text PDFThe thermodynamic stability of 1 : 1 and 2 : 1 boron-nitrogen (B←N) adducts formed between aromatic boronic esters with mono- and diamines was studied in solution by NMR and UV-vis spectroscopy with association energies (ΔG°) ranging from -11 to -28 kJ mol . The effect of different substituents in the boronic ester, the nature of the diamine linker, and the effect of the solvent was explored. Stable 2 : 1 B←N adducts with diamines such as 1,3-diaminopropane were produced in solutions of hydrogen-bonding acceptor solvents (acetonitrile and ethyl acetate), which can be isolated in the solid state as crystalline solvates, whereas the use of noncoordinating solvents such as 1,2-dichloroethane afforded mainly 1 : 1 B←N adducts.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
June 2019
Two crystallographically independent mol-ecules ( and ) are present in the asymmetric unit of the title compound, CHINOS, which differ mainly in the dihedral angle between the phenyl and thia-zole rings [38.94 (16) and 32.12 (15)°, respectively].
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
October 2017
The title compound, CHO [systematic name: 6a,6 b,8a,9a,12a,14b)-4,4,6a,6;b,8a,14b-hexa-methyl-12-methyl-eneicosa-hydro-3-phenanthro[1',2':6,7]indeno-[2,1-]furan-3,11(2)-dione], is a triterpene lactone, which was isolated from di-chloro-methane extract of (Turcz.) Lundell (celastraceae) stem bark. The compound has a lupane skeleton and consists of four fused six-membered rings and two five-membered rings.
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