Publications by authors named "Angajendra Ghosh"
Objectives: Opioid use disorder is extremely common. Many long-term opioid users will have their first exposure to opioids in hospitals. We aimed to compare long-term opioid use in patients who received fentanyl vs.
View Article and Find Full Text PDFBackground: The dose equivalency of fentanyl vs. morphine is widely considered to be approximately 1:100. However, little is known about the effect of age on this ratio when these agents are used as infusions for analgosedation.
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- Guidelines suggest maintaining normal carbon dioxide levels for adults in a coma resuscitated from cardiac arrest, but mild higher levels may help increase brain blood flow and improve outcomes.
- In a study involving 1,700 patients, participants were randomly assigned to either mild hypercapnia or normocapnia for 24 hours and were assessed 6 months later for neurologic recovery.
- Results showed no significant difference in favorable neurological outcomes or mortality between the two groups, indicating that mild hypercapnia did not improve recovery compared to normal levels.
There is significant interest in the potential for nebulised unfractionated heparin (UFH), as a novel therapy for patients with COVID-19 induced acute hypoxaemic respiratory failure requiring invasive ventilation. The scientific and biological rationale for nebulised heparin stems from the evidence for extensive activation of coagulation resulting in pulmonary microvascular thrombosis in COVID-19 pneumonia. Nebulised delivery of heparin to the lung may limit alveolar fibrin deposition and thereby limit progression of lung injury.
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- A study was conducted in two adult ICUs to compare the effects of continuous infusion of fentanyl versus morphine on patient outcomes during mechanical ventilation.
- The trial included 681 patients and found that those receiving fentanyl had a higher median number of ventilator-free days at Day 28 compared to those on morphine.
- Results suggested that the choice of opioid can significantly impact clinical outcomes, particularly the duration of time patients spent off the ventilator and their overall ICU stay.
Objective: There is a growing recognition of the impact of lockdowns on non-COVID-19 demand for critical care services. While a reduction in demand has been postulated, there remains a paucity of quantitative data on the extent and nature of this reduction. The present study aims to quantify the impact of lockdown on critical care services, namely ED, intensive care unit (ICU), medical emergency team (MET) and emergency theatre (ET) demand, during the lockdown in Victoria, Australia.
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- This study investigates the effects of nebulised heparin on lung injury in mechanically ventilated patients at risk for acute respiratory distress syndrome (ARDS), addressing the long-term impairments survivors may face.
- Conducted as a multicenter, double-blind trial, it randomized adult intensive care patients to receive either nebulised heparin or a placebo while on invasive ventilation.
- The primary goal was to assess whether heparin could improve physical function at 60 days post-treatment, measured by the Short Form 36 Health Survey Score.
Objective: To survey and compare the type and management of foreign bodies found in adult and paediatric ears presenting to an Australian otorhinolaryngology and a general ED.
Methods: Retrospective case study with data collated from two centres. Chart reviews of a total of 330 patients presenting with aural foreign bodies to the ED of the Royal Victorian Eye and Ear Hospital and the ED of The Bendigo Hospital, both situated in the state of Victoria, Australia, were surveyed for patient demographics, foreign body description and referral and removal pattern.