Congenital hydrocephalus (CH), characterized by cerebral ventriculomegaly (CV), is among the most common and least understood pediatric neurosurgical disorders. We have identified in the largest-assembled CV cohort (>2,697 parent-proband trios) an exome-wide significant enrichment of protein-altering de novo variants (DNVs) in LDB1 (p = 1.11 x 10-15).
View Article and Find Full Text PDFPurpose: This systematic review and meta-synthesis seeks to explore cancer patients' journey towards resiliency. The secondary aim of this review is to identify unique resilience protective factors among cancer patients.
Methods: A thorough search was conducted in eight electronic databases and the grey literature for published or unpublished qualitative and mixed methods studies.
Integration of resonators impacts the utilization of the 3-µm-thick silicon-on-insulator (SOI) platform in photonics integrated circuits (PICs). We propose an integrated resonator leveraging a deep-etch silicon waveguide. Through the utilization of a tunable coupler based on multimode interferometers (MMIs), the resonator achieves high fabrication tolerance and reconfigurability.
View Article and Find Full Text PDFLearning of adaptive behaviors requires the refinement of coordinated activity across multiple brain regions. However, how neural communications develop during learning remains poorly understood. Here, using two-photon calcium imaging, we simultaneously recorded the activity of layer 2/3 excitatory neurons in eight regions of the mouse dorsal cortex during learning of a delayed-response task.
View Article and Find Full Text PDFJ Neuropathol Exp Neurol
March 2023
The COVID-19 pandemic has had a significant impact on medical services. Many countries postponed nonemergent procedures to preserve hospital resources for the unprecedented situation. Surgical backlogs caused by the COVID-19 pandemic have been evaluated by different groups.
View Article and Find Full Text PDFDrug-resistant epilepsy, defined as the failure of 2 or more antiseizure medications to achieve seizure freedom, is responsible for 2/3 of epilepsy cases. Tumors are responsible for up to 15% of all adult onset and up to 6% of childhood onset epilepsies. Among these tumors, commonly known subtypes DNET, ganglioglioma, and low-grade astrocytoma are often suspected.
View Article and Find Full Text PDFAn integrated aerodynamic three-hole pressure probe (THP) based on a fiber-optic tip sensor array for high-velocity flow field vector measurement is developed and demonstrated in wind tunnel testing. The sensor array consisting of three miniature pressure fiber-tip sensors is integrated into three pressure conduits inside top area of the THP, which serves to mitigate pneumatic pressure loss and is expected for a more reliable analysis of flow characteristics. Fast real-time data acquisition is implemented by a compact self-developed multichannel white light interferometry (WLI) interrogator.
View Article and Find Full Text PDFClin Neuropathol
September 2022
A stillbirth fetus with semilobar holoprosencephaly was induced at 24 weeks gestational age. While the eyes appeared unremarkable externally, there was an absence of optic nerves. At the ventral hypothalamicdiencephalic region there was an area of bilateral epithelioid cells containing melanin.
View Article and Find Full Text PDFDensity functional theory method at the B3LYP/6-31G level was used to determine the structure of 12mer single-strand guanine oligomers. The length and width of the optimized structure are 38.7 and 18.
View Article and Find Full Text PDFNeuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires interpretation of tau morphology based on extensive brain sampling. Here we report subcortical tau burden is sufficient to distinguish PSP and CBD, regardless of the tau morphology. The tau pallido-claustral ratio is a promising diagnostic indicator for PSP and CBD.
View Article and Find Full Text PDFUsing fusion splicing and hydroxide catalysis bonding (HCB) technology, an all-silica inline fiber-optic sensor with high-pressure survivability, high-resolution salinity measurement capability, and corrosion resistance for deep sea explorations is proposed and experimentally demonstrated. Two extrinsic Fabry-Perot interferometers (EFPIs) and a fiber Bragg grating (FBG) are cascaded in one single-mode fiber (SMF), enabling structural integration of single lead-in fiber and versatility of the sensing probe for temperature, depth, and salinity monitoring. The HCB technology offers a polymer adhesive-free assembly of one open-cavity EFPI for refractive index (RI) (salinity) sensing under normal pressure and temperature (NPT) conditions, showing obvious advantages of strong bonding strength, reliable effectiveness, and no corrosive chemicals requirements.
View Article and Find Full Text PDFNeurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), can be clinically heterogeneous which may be explained by the co-inheritance of multiple genetic variants that modify the clinical course. In this study we examine variants in three genes in a family with one individual presenting with ALS and lipodystrophy. Sequencing revealed a p.
View Article and Find Full Text PDFDensity functional theory computational investigation was performed to study the electronic structures, muon sites, and the associated hyperfine interactions in [Au(SR)] and [Au(SeR)] where R is phenylethane. The calculated electronic structures show inhomogeneous spin density distribution and are also affected by different ligands. The two most stable muon sites near Au atoms in the thiolated system are MAu11 and MAu6.
View Article and Find Full Text PDFA differential-pressure fiber-optic airflow (DPFA) sensor based on Fabry-Perot (FP) interferometry for wind tunnel testing is proposed and demonstrated. The DPFA sensor can be well coupled with a Pitot tube, similar to the operation of the differential diaphragm capsule in the airspeed indicator on the aircraft. For differential pressure sensing between total pressure and static pressure in the airflow, an FP cavity is formed between the sensing diaphragm and a fiber end-face, and a tubule is inserted into the FP cavity.
View Article and Find Full Text PDFJ Clin Neurosci
August 2020
Clinical and neuropathological overlap of two or more neurodegenerative diseases (ND) is not an uncommon occurrence yet is still underdiagnosed in clinical neurological and neuropathological. The authors present a clinicopathological overview of the current understanding of overlapping ND's with the hope that this review will encourage further studies that are required to investigate the effect of such overlaps on clinical presentations and how often clinical presentations raise the suspicion of multiple ND's. The authors suggest that as more patients with overlapping ND's come to light, traditional classification system of ND's may need to be modified.
View Article and Find Full Text PDFInt J Environ Res Public Health
November 2019
As there are few food frequency questionnaires (FFQ) to assess the dietary intake of preschool children, this study examined the validity and reliability of an FFQ for this purpose. A total of 210 preschoolers aged 4 to 6 years participated in the validation study, while a subsample of 66 participants joined the reliability study. The FFQ is modified from the ToyBox-study and South East Asian Nutrition Surveys (SEANUTS), and comprised 108 food items from 13 food groups.
View Article and Find Full Text PDFCurcuminoids have been long proven to possess antioxidant, anti-inflammatory and antibacterial properties which are crucial in their role as a pharmacological active agent. However, its poor solubility, high oxidative degradation, light sensitivity and poor bioavailability have been huge hurdles that need to be overcome for it to be administered as an oral or even a topical medication. In this present study, a complex coacervation microencapsulation approach was used to encapsulate the curcuminoids using both gelatin B and chitosan (at the optimum ratio of 30:1% /) for a more efficient drug delivery system.
View Article and Find Full Text PDFCurcuminoids have been used for the management of burns and wound healing in traditional Chinese medicine practices but the wide application of curcuminoids as a healing agent for wounds has always been a known problem due to their poor solubility, bioavailability, colour staining properties, as well as due to their intense photosensitivity and the need for further formulation approaches to maximise their various properties in order for them to considerably contribute towards the wound healing process. In the present study, a complex coacervation microencapsulation was used to encapsulate curcuminoids using gelatin B and chitosan. This study also focused on studying and confirming the potential of curcuminoids in a microencapsulated form as a wound healing agent.
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