Electron Beam Radiation as a Safe Method for the Sterilization of Aceclofenac and Diclofenac-The Usefulness of EPR and H-NMR Methods in Determination of Molecular Structure and Dynamics.

Diclofenac (DC) [2-(2,6-Dichloroanilino)phenyl]acetic acid,) and aceclofenac (AC) 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid in substantia were subjected to ionizing radiation in the form of a beam of high-energy electrons from an accelerator in a standard sterilization dose of 25 kGy and higher radiation doses (50-400 kGy). We characterized non-irradiated and irradiated samples of DC and AC by using the following methods: organoleptic analysis (color, form), spectroscopic (IR, NMR, EPR), chromatographic (HPLC), and others (microscopic analysis, capillary melting point measurement, differential scanning calorimetry (DSC)). It was found that a absorbed dose of 50 kGy causes a change in the color of AC and DC from white to cream-like, which deepens with increasing radiation dose.

APTES-Modified SBA-15 as a Non-Toxic Carrier for Phenylbutazone.

Improvement of the bioavailability of poorly soluble medicinal substances is currently one of the major challenges for pharmaceutical industry. Enhancing the dissolution rate of those drugs using novel methods allows to increase their bioavailability. In recent years, silica-based mesoporous materials have been proposed as drug delivery systems that augment the dissolution rate.

Improved solubility of lornoxicam by inclusion into SBA-15: Comparison of loading methods.

An increasing proportion of new medicinal substances are poorly soluble in water. Adsorption on mesoporous silicas increases their bioavailability when administered orally. Loading method determines adsorption either on the surface in crystalline state or inside the mesopores in amorphus form.

Review of Recent Developments of Glass Transition in PVC Nanocomposites.

This review addresses the impact of different nanoadditives on the glass transition temperature () of polyvinyl chloride (PVC), which is a widely used industrial polymer. The relatively high limits its temperature-dependent applications. The objective of the review is to present the state-of-the-art knowledge on the influence of nanofillers of various origins and dimensions on the of the PVC.

Modification of the Release of Poorly Soluble Sulindac with the APTES-Modified SBA-15 Mesoporous Silica.

The effectiveness of oral drug administration is related to the solubility of a drug in the gastrointestinal tract and its ability to penetrate the biological membranes. As most new drugs are poorly soluble in water, there is a need to develop novel drug carriers that improve the dissolution rate and increase bioavailability. The aim of this study was to analyze the modification of sulindac release profiles in various pH levels with two APTES ((3-aminopropyl)triethoxysilane)-modified SBA-15 (Santa Barbara Amorphous-15) silicas differing in 3-aminopropyl group content.

Poly(-Lactic Acid)/Pine Wood Bio-Based Composites.

Bio-based composites made of poly(-lactic acid) (PLLA) and pine wood were prepared by melt extrusion. The composites were compatibilized by impregnation of wood with γ-aminopropyltriethoxysilane (APE). Comparison with non-compatibilized formulation revealed that APE is an efficient compatibilizer for PLLA/wood composites.

Study of cross - relaxation and molecular dynamics in the solid 3-(trifluoromethyl) benzoic acid by solid state NMR off - resonance.

Molecular dynamics of the solid 3-(trifluoromethyl) benzoic acid containing proton H and fluorine F nuclei was explored by the solid-state NMR off - resonance technique. Contrary to the previous experiments the proton nuclei system I relaxed in the off - resonance effective field B→ while fluorine nuclei system S was saturated for short time in comparison to the relaxation time T. New cross - relaxation solid - state NMR off - resonance experiments were conducted on a homebuilt pulse spectrometer operating at the on-resonance frequency of 30.

Local motions in poly(ethylene-co-norbornene) studied by (1)H NMR relaxometry.

Molecular motions in poly(ethylene-co-norbornene) were studied in a temperature range well below its glass transition point by a few techniques based on the NMR phenomenon. Temperature dependencies of proton spin-lattice relaxation times T1 (at 200 MHz and at 30.2 MHz), proton spin-lattice relaxation time in the rotating frame T1ρ (at 68 kHz) and frequency dispersion of proton spin-lattice off-resonance relaxation times in the rotating frame T1ρ(off) were determined for the copolymer.

Methodology for solid state NMR off-resonance study of molecular dynamics in heteronuclear systems.

Methodology for the study of dynamics in heteronuclear systems in the laboratory frame was described in the previous paper [1]. Now the methodology for the study of molecular dynamics in the solid state heteronuclear systems in the rotating frame is presented. The solid state NMR off-resonance experiments were carried out on a homemade pulse spectrometer operating at the frequency of 30.

Methodology for solid state NMR study of cross relaxation and molecular dynamics in heteronuclear systems.

This work presents the theoretical analysis of cross-relaxation and its applications to the study of molecular dynamics in the solid state heteronuclear systems in the laboratory frame. The solid state NMR experiments were carried out on a homemade pulse spectrometer operating at the frequency of 30.2 MHz and 28.