Publications by authors named "Aneta Grzesiak"
Article Synopsis
- The Hammersmith Score (HS) is a validated prognostic tool that helps predict response and survival rates in early-phase cancer trial participants based on routine biochemical measures.
- A study analyzed 212 patient referrals, finding that HS significantly predicted overall survival and outperformed the Royal Marsden Score (RMS) in its predictive ability.
- HS offers a simple and cost-effective method to improve patient selection and referral for early-phase cancer trials, especially in the context of modern cancer immunotherapy.
The aim of this study was to evaluate whether the differences in plasma 17beta-estradiol concentration in early and late follicular phases of the menstrual cycle can affect the level of endogenous DNA damage in lymphocytes assessed by comet assay, and whether the extent of this damage in the follicular phase is associated with the genotype of catechol-O-methyltransferase (COMT). The level of DNA damage was positively correlated with 17beta-estradiol concentration only in the late follicular phase. Subjects with the COMT L/L homozygous mutated variant revealed more DNA damage as compared to individuals with the COMT wild-type and heterozygous (H/L+HH) genotype.
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