Cyclosporine A - treated nephrotic children show impaired vasodilatation but no autonomic neuropathy.

Introduction: The aim of the study was to determine the effect of long-term cyclosporine A (CsA) treatment in children with idiopathic nephrotic syndrome on autonomic nerve function and peripheral blood flow assessed with thermography.

Material And Methods: The study group consisted of 19 nephrotic children treated with cyclosporine A compared to 16 healthy children. The assessment of blood flow was made based on the results of thermographic measurements during the cold stress test by an infrared radiation registering camera.

[Homocysteine and glutathione metabolism in steroid-treated relapse of idiopathic nephrotic syndrome].

Unlabelled: Changes in metabolism of aminothiols may have an influence on endothelial function or change the red-ox balance. The aim of study was designed to assess changes in plasma aminothiols': proatherogenic (homocysteine-HCY) and antiatherogenic (glutathione-GSH) metabolism in nephrotic syndrome in children.

Material And Methods: The study group included 77 nephrotic children (aged 2-18 years) divided into four groups, i.

[Carriage of Streptococcus pneumoniae in nasopharynx in children with nephrotic syndrome aged 2-5 years in Poland].

Children with nephrotic syndrome (NS) are at increased risk of Streptococcus pneumoniae infections. Streptococcus pneumoniae carrier state in the nasopharynx is an early stage of this infections. The aim of the study was to assess carriage rate and characterise bacterial isolates of Streptococcus pneumoniae among children with NS in a prospective multicentre study involving 10 nephrologic centres in Poland.

Markers of endothelial dysfunction in children with idiopathic nephrotic syndrome.

Endothelial function impairment may constitute a link between nephrotic syndrome and atherosclerosis. We assessed changes in plasma thrombomodulin, von Willebrand factor and plasminogen activator inhibitor-1 at different stages of idiopathic nephrotic syndrome in children and correlated them with clinical and biochemical parameters. The study group included 132 nephrotic children (aged 2-18 years) divided into four groups, i.

Ectopic mediastinal parathyroid carcinoma as a cause of dialysis-dependent renal failure.

Carcinoma of the parathyroid gland is infrequent in patients with secondary hyperparathyroidism. Typical clinical symptoms are related to the presence of a neck mass and hypercalcemia. We describe a case of a 55-year-old man in whom primary parathyroid carcinoma led most likely to the development of end-stage dialysis-dependent renal failure, and the diagnosis of the cancer was delayed due to ectopic localization of the tumor, and dramatic complications in the clinical course of the disease, including acute pancreatitis and peritionitis.

[Insulinsensitivity and beta-cell function in children with idiopathic nephrotic syndrome].

Glucose intolerance which is frequently found in patients with the idiopathic nephrotic syndrome (INS) may be linked to an increased cardiovascular risk in these patients. Recently it has been suggested that proteinuria and steroid treatment may independently affect insulin sensitivity. The aim of the study was to assess insulin resistance (IR) and beta-cell function in children with INS at various stages of the disease.

[Assessment of the peripheral circulation in children with nephrotic syndrome treated with cyclosporin A].

Cyclosporin A (CsA) is an immunosuppressive agent used in children for the treatment of steroid-dependent idiopathic nephrotic syndrome (INS). Despite its benefitial effect on a course of the disease CsA may exert nephrotoxic effects because of its vasoconstrictive properties. CsA-dependent disorders of the peripheral flow (Raynaud phenomenon--RP) have been recently described.

Peritoneal clearance of homocysteine with icodextrin or standard glucose solution exchange.

Background: The aim of the study was to assess plasma homocysteine concentration in peritoneal dialysis patients, and to compare the effect of different peritoneal solutions (glucose-based and icodextrin-based) on peritoneal clearance of homocysteine.

Methods: The study group comprised 10 chronic peritoneal dialysis patients; the control group comprised 15 healthy, age-matched non-obese subjects with normal renal function. Patients with vitamin B(12) or folate deficiency were excluded.

Raynaud's phenomenon and endothelial dysfunction in end-stage renal disease patients treated with hemodialysis.

Background/aims: Steal syndrome is a well-known complication of arteriovenous shunt placement. Increased frequency of Raynaud's phenomenon (RP) especially concerning shunt limb is reported among hemodialysis (HD) patients. The aim of the study was to assess the relation of impairment of peripheral circulation diagnosed with cold stress test (CST) and thermography to the AV shunt location and markers of endothelial dysfunction in HD patients.

[Assessment of children at the beginning of renal replacement therapy in Lodz 1990-2000].

The time of patients' referral to dialysis predicts the clinical outcome of the therapy and significantly influences the mortality rate. The aim of the study was to assess the clinical and nutritional status and selected biochemical parameters (serum creatinine, urea, bicarbonate, calcium, albumin concentration) at the beginning of renal replacement therapy. We analysed medical history of 46 children (24 boys; 22 girls) aged 1 month-18 years (mean age 13.

[Analysis of renal replacement therapy in patients with renal failure].

The article presents the 10-years experience of renal replacement therapy in a single centre. A total of 158 patients were treated in this period. 77 patients (47 F, 30 M, mean age 18.

[Hypertension in pregnancy--risk factors, prevention and treatment].

The term hypertension in pregnancy stands either for a high blood pressure, which has already developed before pregnancy (i.e., chronic hypertension in pregnancy), or for a pregnancy-associated disease (i.

[Pneumoperitoneum and peritonitis in a child treated by continuous ambulatory peritoneal dialysis].

Pneumoperitoneum is a rare complication of peritoneal dialysis, which in most cases occurs soon after the implantation of the peritoneal catheter and does not need any specific treatment. In contrast, pneumoperitoneum due to visceral perforation represents a serious clinical problem and usually needs an urgent surgical intervention. We present a case of a 10-year old girl treated by peritoneal dialysis for 7 months who was admitted to hospital with symptoms of peritonitis and pneumoperitoneum.

[Dialysis-related complications in peritoneal dialysis patients].

The hospital records of 56 patients (25M, 31F) with acute or chronic renal failure treated by peritoneal dialysis were retrospectively reviewed. Mean dialysis time was 13 +/- 15 days in acute renal failure and 32 +/- 23 months in chronic renal failure. The incidence of infectious (exit site infections and peritonitis) and non-infectious dialysis-related complication was assessed.