Publications by authors named "Aner Daum"
The clinical benefit of lipid-lowering therapies is to reduce circulating levels of atherogenic particles and to ameliorate the risk of atherosclerotic cardiovascular disease (ASCVD). The completion of two major clinical trials on PCSK9 inhibitors (PCSK9i), the FOURIER and the ODYSSEY outcome trials, has marked the beginning of a new era of lipid-lowering drugs. PCSK9i, evolocumab and alirocumab, are monoclonal antibodies that inactivate the liver proprotein convertase subtilisin kexin 9 (PCSK9).
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- The study evaluated the effects of the intra-aortic balloon pump (IABP) treatment on patients with cardiogenic shock before and after the European Society of Cardiology (ESC) revised its guidelines in 2012, downgrading IABP's use.
- Data from the Acute Coronary Syndrome Israeli Survey identified a 24% drop in IABP use and showed that prior to the guideline change, IABP provided better clinical outcomes compared to conventional therapy, but this benefit diminished afterward.
- Following the guideline updates, IABP is now mainly used for high-risk patients, which has limited its effective application and overall positive outcomes in treating cardiogenic shock.
Background: Diabetes mellitus (DM) is a common and increasingly prevalent condition in patients with atrial fibrillation (AFib). The left atrium appendage (LAA), a small outpouch from the LA, is the most common location for thrombus formation in patients with AFib.
Hypothesis: In this study, we examined LAA remodeling differences between diabetic and nondiabetic patients with AFib.
Goblet cell carcinoid or carcinoma (GCC) is a rare tumor found incidentally during routine management of acute appendicitis. GCCs are more aggressive compared with conventional appendiceal tumors but less aggressive compared with adenocarcinomas, and they often present with serosal and mesoappendiceal involvement. We herein report two cases of acute appendicitis in a 45-year-old female and a 60-year-old male with varied clinical symptoms.
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- Coronary Artery Ectasia (CAE) is a condition where one or more coronary arteries become dilated, often analyzed in patients suspected of having ischemic heart disease.
- A study of 4000 patients identified 171 with CAE, significant obstructive coronary artery disease, or normal coronary angiograms, finding a strong link between low high-density lipoprotein cholesterol (HDL-C) levels and CAE.
- It was noted that low HDL-C increases CAE risk significantly, while elevated hemoglobin levels can double the risk, suggesting that changes in cholesterol and hemoglobin levels can lead to coronary artery complications.
Implantable cardioverter-defibrillator endocarditis is a rare and potentially life threatening complication of brucellosis of difficult management for clinicians. We report an unusual case of pacemaker-related endocarditis due to in a patient with previous history of neurobrucellosis. Our patient was admitted to a hospital with severe swelling of his pacemaker pocket implanted 8 years earlier for sick sinus syndrome.
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