Publications by authors named "Anelise Baptista da Silva"
Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and Exposure.
Fernanda Fries da Silva Josiane Delgado Paz Raoní Scheibler Rambo Guilherme Arraché Gonçalves Mauro Neves Muniz Lovaine Silva Duarte Anelise Baptista da Silva
J Med Chem
December 2024
Article Synopsis
- The research focuses on developing a new set of 4-alkoxyquinolines aimed at treating tuberculosis, particularly against both regular and drug-resistant strains.
- The key compound shows good solubility and stability, even in harsh acidic environments, making it a strong candidate for further testing.
- Despite some challenges with absorption and metabolism, it demonstrated effectiveness in laboratory models, indicating potential for use as an antituberculosis drug.
Healthcare-associated infections (HAIs) represent a global challenge and an even more staggering concern when related to microorganisms capable of resisting and surviving for long periods in the environment, such as Acinetobacter spp. Strategies that allow a reduction of pathogens from hospital environments represent an additional barrier in infection control protocols, minimizing transmission to hospitalized patients. Considering the antimicrobial properties of copper, here, the bacterial load and the presence of Acinetobacter spp.
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