Serum Concentrations of Endothelin-1 and Matrix Metalloproteinases-2, -9 in Pre-Hypertensive and Hypertensive Patients with Type 2 Diabetes.

Endothelin-1 (ET-1) is one of the most potent vasoconstrictors known to date. While its plasma or serum concentrations are elevated in some forms of experimental and human hypertension, this is not a consistent finding in all forms of hypertension. Matrix metalloproteinases -2 and -9 (MMP-2 and MMP-9), which degrade collagen type IV of the vascular basement membrane, are responsible for vascular remodeling, inflammation, and atherosclerotic complications, including in type 2 diabetes (T2D).

Effect of Aronia melanocarpa fruit juice on amiodarone-induced pneumotoxicity in rats.

Background: The fruits of Aronia melanocarpa (Michx.) Elliot is extremely rich in biologically active polyphenols.

Objective: We studied the protective effect of A.

Zinc content in the diet affects the activity of Cu/ZnSOD, lipid peroxidation and lipid profile of spontaneously hypertensive rats.

The present study focused on the effect of Zn containing diets on the activity of superoxide dismutase (Cu/ZnSOD), systolic blood pressure (SBP), lipid peroxides (ROOH) and lipids (LDL, HDL, triglycerides and cholesterol) in male spontaneously hypertensive rats (SHR). Three experimental groups of animals were studied: a control (G1-40 mg), and two with zinc-supplemented diets (G2-100 and G3-160 mg Zn/kg lab chow). The diets were introduced at the beginning of the development of hypertension (2 months after birth) and the animals were fed for 8 weeks.

Changes in the activity of Cu/Zn superoxide dismutase, lipid profile and aorta morphology of spontaneously hypertensive rats on zinc diet.

Unlabelled: The aim of the present study was to investigate the effect of zinc on the activity of copper-zinc superoxide dismutase (Cu/Zn SOD), the lipid profile, the arterial blood pressure and the morphological changes of the aorta in male spontaneously hypertensive rats (SHR).

Materials And Methods: The study included 52 male SHR animals. The animals were randomly asigned into three groups to be fed one of three zink diets--in group one animals (G1, control group) the zinc content was 50 mg/kg, in group two (G2)--155 mg/kg and in group three (G3) 250 mg/kg.

Effect of zinc on the activity of Cu/Zn superoxide dismutase and lipid profile in Wistar rats.

Aim: The aim of the present study was to analyze the effect of zinc on the activity of Cu/ZnSOD, lipid profile and arterial blood pressure in male Wistar rats.

Material And Methods: The study included 53 male Wistar rats with basal weight 190-210 g. The animals were divided into three groups and put on diets with different zinc content.