Publications by authors named "Anees M K Puthenpeedikakkal"
Article Synopsis
- * The research investigates how the m3C32 modification affects the structure of the anticodon stem loop in human tRNA-Arg-UCU-4-1, revealing that it can disrupt nearby base pairings while still stabilizing the overall structure.
- * Although m3C32 modification leads to some structural changes, it maintains the essential pairing for tRNA function in translation, suggesting it may influence interactions with binding partners without compromising functionality.
The essential pre-mRNA splicing factor U2AF2 (also called U2AF65) identifies polypyrimidine (Py) tract signals of nascent transcripts, despite length and sequence variations. Previous studies have shown that the U2AF2 RNA recognition motifs (RRM1 and RRM2) preferentially bind uridine-rich RNAs. Nonetheless, the specificity of the RRM1/RRM2 interface for the central Py tract nucleotide has yet to be investigated.
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