A feasibility and pilot additive randomised control trial of attachment security priming during behavioural activation.

Background: There is some initial evidence that attachment security priming may be useful for promoting engagement in therapy and improving clinical outcomes.

Aims: This study sought to assess whether outcomes for behavioural activation delivered in routine care could be enhanced via the addition of attachment security priming.

Method: This was a pragmatic two-arm feasibility and pilot additive randomised control trial.

An effect of inhibitory load in children while keeping working memory load constant.

Children are slower and more error-prone when the correct response is counter to their initial inclination (incongruent trials) than when they just need to do what comes naturally (congruent trials). Children are almost always tested on a congruent-trial block and then on an incongruent-trial block. That order of testing makes it impossible to determine whether worse performance on incongruent trials is due to the need to inhibit a pre-potent response, the need to clear the rule for Block 1 from working memory, some other demand of task-switching, or some combination of these.

Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.

Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines.