Differences in Lift Quality During the Barbell Back Squat When Using Perceived Recovery Status-Regulated Intrasession Recovery Compared With Standardized Recovery Intervals.

Wolfe, AA, Laurent, CM, Tolusso, DV, and Rinehart, AN. Differences in lift quality during the barbell back squat when using perceived recovery status-regulated intrasession recovery compared with standardized recovery intervals. J Strength Cond Res 38(3): 444-449, 2024-The current investigation examined kinetic differences between standardized and perceptually regulated rest internals during power-based resistance training.

Suppression of intestinal tumorigenesis in mutant mice upon Musashi-1 deletion.

Therapeutic strategies based on a specific oncogenic target are better justified when elimination of that particular oncogene reduces tumorigenesis in a model organism. One such oncogene, Musashi-1 (), regulates translation of target mRNAs and is implicated in promoting tumorigenesis in the colon and other tissues. Msi-1 targets include the tumor suppressor adenomatous polyposis coli (), a Wnt pathway antagonist lost in ∼80% of all colorectal cancers.

Yes-associated protein is involved in proliferation and differentiation during postnatal liver development.

It is known that the liver undergoes size increase and differentiation simultaneously during the postnatal period. Cells in the liver undergo a period of well-controlled proliferation to achieve the adult liver-to-body weight ratio. The postnatal liver growth is also accompanied by simultaneous hepatic differentiation.

Deregulation of Hippo kinase signalling in human hepatic malignancies.

Background/aims: Hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and hepatoblastoma (HB) are the main hepatic malignancies with limited treatment options and high mortality. Recent studies have implicated Hippo kinase pathway in cancer development, but detailed analysis of Hippo kinase signalling in human hepatic malignancies, especially CC and HB, is lacking.

Methods: We investigated Hippo kinase signalling in HCC, CC and HB using cells and patient samples.

Increased activation of the Wnt/β-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice.

Farnesoid X receptor (FXR), the primary bile acid-sensing nuclear receptor, also is known for its anticancer properties. It is known that FXR deficiency in mice results in spontaneous hepatocellular carcinoma (HCC), but the mechanisms are not completely understood. We report that sustained activation of the Wnt/β-catenin pathway is associated with spontaneous HCC in FXR-knockout (KO) mice.