Implementation of SNOMED CT in an online clinical database.

A number of strategies have been published to accelerate the use of electronic health records in caring for patients across the UK. These visions of 'eHealth' have a common requirement for robust interoperability between different systems with the use of appropriate information and data standards. SNOMED CT, a comprehensive terminology that NHS England intends to adopt across all care settings by 2020, is a key component of these standards but there is currently limited experience in its use in live clinical settings.

Quantifying multifaceted needs captured at the point of care. Development of a Disabilities Terminology Set and Disabilities Complexity Scale.

Aims: To develop a Disabilities Terminology Set and quantify the multifaceted needs of disabled children and their families in a district disability clinic population.

Method: Data from structured electronic clinic letters of children attending paediatric disability clinics from June 2007 to May 2012 in Sunderland, north-east England collected at the point of clinical care were analysed to determine appropriate terms for consistent recording of each need and issue. Terms were collated to count the number of needs per child.

Neonatal nurse staffing and delivery of clinical care in the SSBC Newborn Network.

Objective: To measure nursing workload and timely completion of essential tasks in relation to the staffing levels recommended by the British Association of Perinatal Medicine (BAPM) in Staffordshire, Shropshire and Black Country Newborn Network.

Methods: A prospective observational study was conducted measuring the time taken by selected nurses to undertake the necessary tasks for babies receiving different levels of care in the Network's six constituent neonatal units. An independent observer was used.

The challenge of the information culture for the paediatrician.

'Liberating the NHS' and the new outcomes framework place information at the heart of the management of the National Health Service (NHS) and develop further the quality framework defined by Lord Darzi. In support of children, paediatricians have a responsibility to understand the informatics agenda and to ensure that data collection is as accurate as possible. There are particular difficulties in supplying a comprehensive health record for children and providing them with the benefits of access to their health records.

PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy.

Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in causing a phenotypic response. Genome-wide RNA interference (RNAi) phenotypic screening has emerged as an effective tool in unveiling the genes essential for specific cellular functions and biological activities.

An intelligent ventilation and oxygenation management system in neonatal intensive care using fuzzy trend template fitting.

This paper describes an open loop feedback intelligent system for neonatal intensive care management. The system provides a tool enabling the user to make the final decision to accept or reject the advice given. The system collects 18 parameters from the bedside monitor and ventilator using a Medical Information Bus (MIB) system.