The introduction emphasizes the need for an in vitro model to detect adverse drug reactions affecting microvascular function and vascular tone.
The PM-1, a new automated perfusion myograph, enables researchers to test the effects of drugs on blood vessels by controlling pressure and flow while also measuring vascular permeability.
Results showed that Ivermectin enhanced flow-mediated dilatation and thrombin increased vessel permeability, demonstrating the PM-1's effectiveness in drug testing for potential vascular responses.