Publications by authors named "Andy MacKinnon"
Article Synopsis
- The study investigates the performance of a 30 J, nanosecond laser system at extreme conditions, focusing on shock drive capabilities.
- It employs a velocity interferometer to measure maximum ablation pressures, revealing pressures over 160 GPa while ensuring a 1D shock profile.
- The analysis indicates that slope pulses generate higher ablation pressures than plateau pulses and that results are comparable to those from the Omega Laser Facility under similar conditions.
Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We tested the small-molecule inhibitor of glutaminase CB-839 in combination with erlotinib on epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) as a therapeutic strategy to simultaneously impair cancer glucose and glutamine utilization and thereby suppress tumor growth. Here, we show that CB-839 cooperates with erlotinib to drive energetic stress and activate the AMP-activated protein kinase (AMPK) pathway in EGFR (del19) lung tumors.
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