Publications by authors named "Andy Gu"
Article Synopsis
- T cells are crucial in the development of systemic lupus erythematosus (SLE), and chronic signaling can lead to T cell exhaustion, reducing their tissue damage capacity.
- Researchers tested an anti-TCRβ monoclonal antibody (mAb) in SLE mouse models, finding that it significantly increased survival rates and reduced kidney damage compared to controls.
- The treatment also altered T cell profiles, increasing regulatory T cells and inducing an exhaustion-like state in CD4 T cells, suggesting that promoting T cell exhaustion could be a beneficial therapeutic strategy for SLE.
Neuroblastoma (NB) is a pediatric tumor of the peripheral nervous system. Approximately 80% of relapsed NB show RAS-MAPK pathway mutations that activate ERK, resulting in the promotion of cell proliferation and drug resistance. Ulixertinib, a first-in-class ERK-specific inhibitor, has shown promising antitumor activity in phase 1 clinical trials for advanced solid tumors.
View Article and Find Full Text PDFT cell stemness and exhaustion coexist as two key contrasting phenomena during chronic antigen stimulation, such as infection, transplant, cancer, and autoimmunity. T cell exhaustion refers to the progressive loss of effector function caused by chronic antigen exposure. Exhausted T (T) cells highly express multiple inhibitory receptors and exhibit severe defects in cell proliferation and cytokine production.
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