Overcoming therapeutic inertia in newly diagnosed type 2 diabetes: Protocol of a randomized, quality improvement trial.

Therapeutic inertia, the delay in the appropriate initiation and intensification of recommended therapies, is a major contributor to the lack of improvement in type 2 diabetes outcomes over the past decade. Therapeutic inertia during the period following diagnosis, when improvements in glycemic control can have lasting benefits, is often overlooked. Technology and team-based care approaches can effectively address therapeutic inertia.

Deciphering Optimal Radar Ensemble for Advancing Sleep Posture Prediction through Multiview Convolutional Neural Network (MVCNN) Approach Using Spatial Radio Echo Map (SREM).

Assessing sleep posture, a critical component in sleep tests, is crucial for understanding an individual's sleep quality and identifying potential sleep disorders. However, monitoring sleep posture has traditionally posed significant challenges due to factors such as low light conditions and obstructions like blankets. The use of radar technolsogy could be a potential solution.

SaccpaNet: A Separable Atrous Convolution-based Cascade Pyramid Attention Network to Estimate Body Landmarks Using Cross-modal Knowledge Transfer for Under-blanket Sleep Posture Classification.

The accuracy of sleep posture assessment in standard polysomnography might be compromised by the unfamiliar sleep lab environment. In this work, we aim to develop a depth camera-based sleep posture monitoring and classification system for home or community usage and tailor a deep learning model that can account for blanket interference. Our model included a joint coordinate estimation network (JCE) and sleep posture classification network (SPC).

Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study.

Objective: To describe the frequency of neuropsychiatric complications among hospitalized patients with coronavirus disease 2019 (COVID-19) and their association with pre-existing comorbidities and clinical outcomes.

Methods: We retrospectively identified all patients hospitalized with COVID-19 within a large multicenter New York City health system between March 15, 2020 and May 17, 2021 and randomly selected a representative cohort for detailed chart review. Clinical data, including the occurrence of neuropsychiatric complications (categorized as either altered mental status [AMS] or other neuropsychiatric complications) and in-hospital mortality, were extracted using an electronic medical record database and individual chart review.

Piezo1 stretch-activated channel activity differs between murine bone marrow-derived and cardiac tissue-resident macrophages.

Macrophages (MΦ) play pivotal roles in tissue homeostasis and repair. Their mechanical environment has been identified as a key modulator of various cell functions, and MΦ mechanosensitivity is likely to be critical - in particular in a rhythmically contracting organ such as the heart. Cultured MΦ, differentiated in vitro from bone marrow (MΦ), form a popular research model.

A Good Farewell? Positive Exits from Federal Housing Assistance and Lower Acute Healthcare Utilization.

Little is known regarding the health outcomes of people who exit from housing assistance and if that experience varies by the circumstances under which a person exits. We asked two questions: (1) does the type of exit from housing assistance matter for healthcare utilization? And (2) how does each exit type compare to remaining in housing assistance in terms of healthcare utilization? This retrospective cohort study of 5550 exits between 2012 and 2018 used data from two large, urban public housing authorities in King County, Washington. Exposures were exiting from housing assistance and type of exit (positive, neutral, negative).

Assessing the impacts of climate variables on long-term air quality trends in Peninsular Malaysia.

Climate change is thought to influence the composition of atmospheric air, but little is known about the direct relationship between these variables, especially in a hot tropical climate like that of Malaysia. This work summarizes and analyzes the climate state and air quality of Peninsular Malaysia based on selected ground-based observations of the temperature, precipitation, relative humidity, wind speed, wind direction and concentrations of PM, O, CO, NO, and SO over the last 20 years (2000-2019). The relationship between the climate state and air quality is analyzed using the Pearson correlation and canonical correlation analysis (CCA) methods is employed to predict the degree of change in the future air quality under different warming scenarios.

Synthesis of a new biocomposite for fertiliser coating: assessment of biodegradability and thermal stability.

The bio- and thermal degradation as well as the water absorption properties of a novel biocomposite comprising cellulose nanoparticles, natural rubber and polylactic acid have been investigated. The biodegradation process was studied through an assembled condition based on the soil collected from the central Malaysian palm oil forests located in the University of Nottingham Malaysia. The effects of the presence of the cellulose nanoparticles and natural rubber on the biodegradation of polylactic acid were investigated.

In-hospital outcomes in patients with and without epilepsy diagnosed with COVID-19-A cohort study.

Objectives: Coronavirus disease 2019 (COVID-19) is associated with mortality in persons with comorbidities. The aim of this study was to evaluate in-hospital outcomes in patients with COVID-19 with and without epilepsy.

Methods: We conducted a retrospective study of patients with COVID-19 admitted to a multicenter health system between March 15, 2020, and May 17, 2021.

Predictors of chronic pain and disability in patients treated conservatively after distal radius fracture: a prospective cohort study.

Purpose: To determine predictors of chronic pain and disability among patients with distal radius fractures (DRF) treated conservatively with closed reduction and cast immobilization.

Methods: This was a prospective cohort study. Information on patient characteristics, post-reduction radiographic parameters, finger and wrist range of motion, psychological status (Hospital Anxiety and Depression Scale or HADS), pain (Numeric Rating Scale or NRS), and self-perceived disability (Disabilities of the Arm, Should, and Hand or DASH) were taken at baseline, cast removal, and 24 weeks.

Associations between greenness and predicted COVID-19-like illness incidence in the United States and the United Kingdom.

Unlabelled: Green spaces may be protective against COVID-19 incidence. They may provide outdoor, ventilated, settings for physical and social activities and therefore decrease transmission risk. We examined the association between neighborhood greenness and COVID-19-like illness incidence using individual-level data.

Underestimation of biomass burning contribution to PM due to its chemical degradation based on hourly measurements of organic tracers: A case study in the Yangtze River Delta (YRD) region, China.

Biomass burning (BB) has significant impacts on air quality and climate change, especially during harvest seasons. In previous studies, levoglucosan was frequently used for the calculation of BB contribution to PM, however, the degradation of levoglucosan (Lev) could lead to large uncertainties. To quantify the influence of the degradation of Lev on the contribution of BB to PM, PM-bound biomass burning-derived markers were measured in Changzhou from November 2020 to March 2021 using the thermal desorption aerosol gas chromatography-mass spectrometry (TAG-GC/MS) system.

A Case of Lance-Adams Syndrome with Mixed Cortical and Reticular Reflex Myoclonus.

Background: Lance Adams syndrome is a chronic post-hypoxic myoclonus.

Phenomenology Shown: This video abstract illustrates Lance Adams Syndrome with mixed cortical and reticular reflex myoclonus in a 32-year-old woman following respiratory arrest in the setting of an asthma attack, as well as improvement in her exam following pharmacologic management.

Educational Value: Lance Adams syndrome can include both cortical and reticular reflex myoclonus features while interdisciplinary intervention and pharmacological treatment can improve symptomatology.

Modeling the impacts of land use/land cover change on meteorology and air quality during 2000-2018 in the Yangtze River Delta region, China.

The land use/land cover (LULC) change in the fast-developing city clusters of China exhibits impacts on both the meteorology and air quality. However, this effect, especially in the Yangtze River Delta (YRD), has not been well quantified. In this study, the LULC data are extracted from Landsat satellite imageries for year 2000 and 2018 for the YRD region.

Continued Virus-Specific Antibody-Secreting Cell Production, Avidity Maturation and B Cell Evolution in Patients Hospitalized with COVID-19.

Understanding the development and sustainability of the virus-specific protective immune response to infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains incomplete with respect to the appearance and disappearance of virus-specific antibody-secreting cells (ASCs) in circulation. Therefore, we performed cross-sectional and longitudinal analyses of peripheral blood mononuclear cells and plasma collected from 55 hospitalized patients up to 4 months after onset of COVID-19 symptoms. Spike (S)- and nucleocapsid (N)-specific IgM and IgG ASCs appeared within 2 weeks accompanied by flow cytometry increases in double negative plasmablasts consistent with a rapid extrafollicular B cell response.

The Effect of Low-Dose Aspirin on Frailty Phenotype and Frailty Index in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly Study.

Background: Frailty is associated with chronic inflammation, which may be modified by aspirin. The purpose of this study was to determine whether low-dose aspirin reduces incident frailty in healthy older adult participants of the ASPirin in Reducing Events in the Elderly (ASPREE) trial.

Methods: In the United States and Australia, 19 114 community-dwelling individuals aged ≥70 and older (U.

The surveillance of spike protein for patients with COVID-19 detected in Hong Kong in 2020.

In 2020, numerous fast-spreading severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been reported. These variants had unusually high genetic changes in the spike (S) protein. In an attempt to understand the genetic background of SARS-CoV-2 viruses in Hong Kong, especially before vaccination, the purpose of this study is to summarize the S protein mutations detected among coronavirus disease 2019 (COVID-19) patients in Hong Kong in 2020.

Collagen IV differentially regulates planarian stem cell potency and lineage progression.

The extracellular matrix (ECM) provides a precise physical and molecular environment for cell maintenance, self-renewal, and differentiation in the stem cell niche. However, the nature and organization of the ECM niche is not well understood. The adult freshwater planarian maintains a large population of multipotent stem cells (neoblasts), presenting an ideal model to study the role of the ECM niche in stem cell regulation.

Anthropogenic emissions of atomic chlorine precursors in the Yangtze River Delta region, China.

Chlorine radical plays an important role in the formation of ozone and secondary aerosols in the troposphere. It is hence important to develop comprehensive emissions inventory of chlorine precursors in order to enhance our understanding of the role of chlorine chemistry in ozone and secondary pollution issues. Based on a bottom-up methodology, this study presents a comprehensive emission inventory for major atomic chlorine precursors in the Yangtze River Delta (YRD) region of China for the year 2017.

Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development.

Cellular plasticity refers to the ability of cell fates to be reprogrammed given the proper signals, allowing for dedifferentiation or transdifferentiation into different cell fates. , this can be induced through direct activation of gene expression, however this process does not naturally occur . Instead, the microenvironment consisting of the extracellular matrix (ECM) and signaling factors, directs the signals presented to cells.

The Silver Lining of COVID-19: Estimation of Short-Term Health Impacts Due to Lockdown in the Yangtze River Delta Region, China.

The outbreak of COVID-19 in China has led to massive lockdowns in order to reduce the spread of the epidemic and control human-to-human transmission. Subsequent reductions in various anthropogenic activities have led to improved air quality during the lockdown. In this study, we apply a widely used exposure-response function to estimate the short-term health impacts associated with PM changes over the Yangtze River Delta (YRD) region due to COVID-19 lockdown.