Publications by authors named "Andy Arnold"
Article Synopsis
- Cannabinoid receptors and their signaling system, found throughout the body including the eye, can be activated by substances like Delta(9)-tetrahydrocannabinol, showing potential for therapeutic benefits in eye health.
- Recent discoveries highlight the presence and localization of proteins that produce and degrade endocannabinoids (eCBs) in the retina, which is crucial for understanding cannabinoid signaling.
- Key findings include the presence of diacylglycerol lipase-alpha in specific retinal cells and the unique localization of proteins like CRIP1a and NAAA, which together define important cannabinoid signaling pathways in the retina's cellular structure.
Depolarization-induced suppression of excitation (DSE) is a major form of cannabinoid-mediated short-term retrograde neuronal plasticity and is found in numerous brain regions. Autaptically cultured murine hippocampal neurons are an architecturally simple model for the study of cannabinoid signaling, including DSE. The transient nature of DSE--tens of seconds--is probably determined by the regulated hydrolysis of the endocannabinoid 2-arachidonoyl glycerol (2-AG).
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