Rethinking orthographic neighbor in Chinese two-character word recognition: Insights from a megastudy.

The influence of orthographic neighbors on visual word recognition is well established in alphabetic scripts. To determine the universality of this effect across writing systems, researchers have been keen on exploring its presence and nature in Chinese word recognition. Given that Chinese is logographic, it necessitates a different definition for orthographic neighbors from the ones used in alphabetic scripts.

Tonal and syllabic encoding in overt Cantonese Chinese speech production: An ERP study.

This study was conducted to investigate how syllables and lexical tones are processed in Cantonese speech production using the picture-word interference task with concurrent recording of event-related brain potentials (ERPs). Cantonese-speaking participants were asked to name aloud individually presented pictures and ignore an accompanying auditory word distractor. The target and distractor either shared the same word-initial syllable with the same tone (Tonal-Syllable related), the same word-initial syllable without the same tone (Atonal-Syllable related), the same tone only (Tone alone related), or were phonologically unrelated.

Comparing word recognition in simplified and traditional Chinese: A megastudy approach.

Although it is well established that the visual complexity of a written word can influence processing, it is far less clear from a cross-script perspective, whether the overall visual complexity of the entire written lexicon also affects word recognition. This question can be answered with the data in megastudy of lexical decision in Chinese (MELD-CH), which was developed with over 800 participants responding to 12,587 simplified and traditional Chinese words. The results showed that lexical decision was slower but more accurate in simplified Chinese, which has about 22.

Cross-cultural adaptation of the Brazilian version of the Speech-Specific Reinvestment Scale - SSRS.

Purpose: To present the cross-cultural equivalence of the Brazilian version of the Specific Reinvestment Scale in Speech - SRRS through its cultural and linguistic adaptation.

Methods: After the SSRS was translated into Brazilian Portuguese, the back-translation was done and the items were compared. Discrepancies were modified by consensus of a committee of SLPs.

Development of a Psychometric Measure of the Propensity to Consciously Control and Monitor Speech Production.

Purpose A speech-specific reinvestment scale (SSRS) is a psychometric measure of the propensity to consciously control and monitor speech production. This study develops and validates an SSRS as well as examines its relationship with speech performance with the moderating effects of trait social anxieties (i.e.

Behavioural evidence for segments as subordinate units in Chinese spoken word production: The form-preparation paradigm revisited.

It is widely acknowledged that phonemic segments are primary phonological units, processed serially, in spoken word production of Germanic languages. However, evidence for a behavioural effect of single-segment overlap on Chinese spoken word production is lacking. The current study adopted the form-preparation paradigm to investigate the effects of segment predictability and segment repetition separately, which were mixed in previous studies.

Effects of Error Experience on Learning to Lower Speech Nasalance Level.

Purpose This research aims to examine the effects of error experience when learning to speak with lowered nasalance level. Method A total of 45 typical speakers were instructed to learn to lower speech nasalance level in either an errorless (restricted possibility for committing errors) or an errorful (unrestricted possibility for committing errors) learning condition. The nasality level of the participants' speech was measured by a nasometer and quantified by nasalance scores (in percent).

Syllable retrieval precedes sub-syllabic encoding in Cantonese spoken word production.

Two experiments were conducted to investigate the time course of syllabic and sub-syllabic processing in Cantonese spoken word production by using the picture-word interference task. Cantonese-speaking participants were asked to name individually presented pictures aloud and ignore an auditory word distractor. The targets and distractors were either phonologically related (i.

Primary phonological planning units in spoken word production are language-specific: Evidence from an ERP study.

It is widely acknowledged in Germanic languages that segments are the primary planning units at the phonological encoding stage of spoken word production. Mixed results, however, have been found in Chinese, and it is still unclear what roles syllables and segments play in planning Chinese spoken word production. In the current study, participants were asked to first prepare and later produce disyllabic Mandarin words upon picture prompts and a response cue while electroencephalogram (EEG) signals were recorded.

Time course of syllabic and sub-syllabic processing in Mandarin word production: Evidence from the picture-word interference paradigm.

The time course of phonological encoding in Mandarin monosyllabic word production was investigated by using the picture-word interference paradigm. Participants were asked to name pictures in Mandarin while visual distractor words were presented before, at, or after picture onset (i.e.

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.

Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies, depositions of insoluble α-synuclein, and other proteins that likely contribute to cellular toxicity and death during the disease. Genetic and biochemical studies have implicated impaired lysosomal and mitochondrial function in the pathogenesis of PD. Transmembrane protein 175 (TMEM175), the lysosomal K channel, is centered under a major genome-wide association studies peak for PD, making it a potential candidate risk factor for the disease.

Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease.

MicroRNA-132 is markedly downregulated in Alzheimer's disease (AD) and related tauopathies, and its levels are closely associated with tau pathology in AD. Whether and how miR-132 contributes to pathology in these neurodegenerative diseases remains unclear. Here, we show that miR-132 and its paralogue miR-212 directly regulate the expression of neuronal nitric oxide synthase (NOS1) through the primate-specific binding site.

Genetic architecture of age-related cognitive decline in African Americans.

Objective: To identify genetic risk factors associated with susceptibility to age-related cognitive decline in African Americans (AAs).

Methods: We performed a genome-wide association study (GWAS) and an admixture-mapping scan in 3,964 older AAs from 5 longitudinal cohorts; for each participant, we calculated a slope of an individual's global cognitive change from neuropsychological evaluations. We also performed a pathway-based analysis of the age-related cognitive decline GWAS.

Syllabic encoding during overt speech production in Cantonese: Evidence from temporal brain responses.

The time course of phonological encoding in overt Cantonese disyllabic word production was investigated using a picture-word interference task with concurrent recording of the event-related brain potentials (ERPs). Participants were asked to name aloud individually presented pictures and ignore a distracting Chinese character. Participants' naming responses were faster, relative to an unrelated control, when the distractor overlapped with the target's word-initial or word-final syllables.

Examining the cognitive demands of analogy instructions compared to explicit instructions.

Purpose: In many learning domains, instructions are presented explicitly despite high cognitive demands associated with their processing. This study examined cognitive demands imposed on working memory by different types of instruction to speak with maximum pitch variation: visual analogy, verbal analogy and explicit verbal instruction.

Method: Forty participants were asked to memorise a set of 16 visual and verbal stimuli while reading aloud a Cantonese paragraph with maximum pitch variation.

MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma.

MicroRNA-10b (miR-10b) is commonly elevated in glioblastoma (GBM), while not expressed in normal brain tissues. Targeted inhibition of miR-10b has pleiotropic effects on GBM derived cell lines, it reduces GBM growth in animal models, but does not affect normal neurons and astrocytes. This data raises the possibility of developing miR-10b-targeting GBM therapy.

Effects of error experience when learning to simulate hypernasality.

Purpose: The purpose of this study was to evaluate the effects of error experience on the acquisition of hypernasal speech.

Method: Twenty-eight healthy participants were asked to simulate hypernasality in either an errorless learning condition (in which the possibility for errors was limited) or an errorful learning condition (in which the possibility for errors was not limited). The nasality level of the participants' speech was measured with a nasometer and reflected by nasalance scores (in percentages).

Analogy instruction and speech performance under psychological stress.

To examine the efficacy of explicit and implicit forms of instruction for speech motor performance under conditions of psychological stress. In experiment 1, 20 participants were asked to deliver a formal presentation to validate the modified Trier Social Stress Test (TSST). In experiment 2, 40 participants were instructed explicitly by verbal explanation or implicitly by analogy to speak with minimum pitch variation and were subjected to psychological stress using the modified TSST.

Influence of analogy instruction for pitch variation on perceptual ratings of other speech parameters.

Purpose: Analogy is the similarity of different concepts on which a comparison can be based. Recently, an analogy of "waves at sea" was shown to be effective in modulating fundamental frequency (F0) variation. Perceptions of intonation were not examined, as the primary aim of the work was to determine whether analogy instruction had a negative impact on other parameters of the speech signal compared with explicit instruction.

Effects of practice schedules on speech motor learning.

The aim of this study was to evaluate the effects of various practice schedules on learning a novel speech task. Forty healthy Cantonese speakers were asked to learn to produce a Cantonese phrase with two target utterance durations (2500 and 3500 milliseconds). They were randomly assigned to one of four learning conditions, each completing a different practice schedule, namely Blocked only, Random only, Blocked-then-Random, and Random-then-Blocked.

Phonological units in spoken word production: insights from Cantonese.

Evidence from previous psycholinguistic research suggests that phonological units such as phonemes have a privileged role during phonological planning in Dutch and English (aka the segment-retrieval hypothesis). However, the syllable-retrieval hypothesis previously proposed for Mandarin assumes that only the entire syllable unit (without the tone) can be prepared in advance in speech planning. Using Cantonese Chinese as a test case, the present study was conducted to investigate whether the syllable-retrieval hypothesis can be applied to other Chinese spoken languages.

Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.

Pathological angiogenesis-driven by an imbalance of pro- and antiangiogenic signaling-is a hallmark of many diseases, both malignant and benign. Unlike in the healthy adult in which angiogenesis is tightly regulated, such diseases are characterized by uncontrolled new vessel formation, resulting in a microvascular network characterized by vessel immaturity, with profound structural and functional abnormalities. The consequence of these abnormalities is further modification of the microenvironment, often serving to fuel disease progression and attenuate response to conventional therapies.

What are effective phonological units in Cantonese spoken word planning?

Two picture-word interference experiments were conducted to investigate the nature of effective phonological units in Cantonese spoken word production. The names of the pictures were Cantonese monosyllables with a consonant+vowel+consonant (CVC) structure. Participants' picture-naming responses were faster when the target (e.

Processing segmental and prosodic information in Cantonese word production.

Five experiments were conducted to investigate how subsyllabic, syllabic, and prosodic information is processed in Cantonese monosyllabic word production. A picture-word interference task was used in which a target picture and a distractor word were presented simultaneously or sequentially. In the first 3 experiments with visually presented distractors, null effects on naming latencies were found when the distractor and the picture name shared the onset, the rhyme, the tone, or both the onset and tone.

The ubiquity of memory retrieval deficits in patients with frontal-striatal dysfunction.

Objective And Background: Previous studies have shown that patients with frontal-striatal dysfunction demonstrate improved performance on tests of recognition memory relative to free recall memory, suggesting deficits in retrieval processes. Not all studies, however, have indicated that all patients with frontal-striatal dysfunction display this profile. In this study, we examined the ubiquity of this "retrieval deficit" profile in a relatively large sample of patients with Parkinson disease (PD) or Huntington disease (HD).