Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients.

Transcription factor 7-like 2 gene (TCF7L2) has been associated with type 2 diabetes. We investigated the association of the rs7903146 SNP in this gene with clinical profile of type 2 diabetes (T2DM) patients. The study involved 980 patients with diabetic nephropathy (44%), diabetic retinopathy (42%), CVD (65%) and early onset of diabetes (45%) and 924 healthy controls.

Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes.

HSPs (heat-shock proteins) are molecular chaperones synthesized under stress conditions, and are involved in renal cell survival and matrix remodelling in acute and chronic renal diseases. In the present study, we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy.

Thoracic impedance measurements during orthostatic change test and during hemodialysis in hemodialyzed patients.

Measurements were performed before and after hemodialysis (HD) in the supine and upright positions (orthostatic change test) and during HD session every 30 minutes in recumbent position on 11 HD patients. Two hydration states were compared: hyperhydration and normal hydration. Each patient served as his own control.

Comparison of prescribed and delivered doses of dialysis using anthropometrically and bioelectrically measured patient volumes.

Background: One of the uncertainties in the prescription of dialysis dose, measured as Kt/V for urea (Kt/Vu), is the volume of urea distribution (V). The aim of our study was to compare two different approaches to estimating V and Kt/V, respectively, and to compare the predicted (prescribed) dose with the actually delivered dose, measured by urea kinetics.

Material/methods: V was estimated using anthropometric measures with the Watson formula (VWatson), and also by multi-frequency bioimpedance analysis (VBIS).

Changes of extracellular volumes measured by whole and segmental bioimpedance analysis during hemodialysis in end-stage renal disease (ESRD) patients.

The bioimpedance technique is postulated as not expensive and non-invasive method for measurement of body water compartments in humans. However, the accuracy of the whole body bioimpedance technique has been questioned by several authors because of nonhomogenic nature of the human body. In the present study we used the whole body bioimpedance technique in comparison to segmental measurement from the arm and leg for assessment of extracellular water compartment.

Concentrations of branched amino acids: isoleucine, valine, leucine in serum of hemodialysis patients during one-year observation.

Malnutrition is commonly reported in haemodialysis patients (HD pts) and is multifactorial in origin. Previous studies indicated a possible relationship between plasma levels of branched-chain amino acids (BCAA): isoleucine, leucine, valine and nutritional status of HD pts. The BCAA have important influence on metabolism of energy in skeletal muscles, in addition the leucine makes easy the synthesis of protein.

Effect of acetate and bicarbonate dialysate on whole body bioimpedance (BIS) and segmental (thoracic) bioimpedance in hemodialysed (HD) patients.

There are sparse data about the influence of dialysis itself on bioimpedance measurement. The aim of this study was to evaluate the influence of dialysis without ultrafiltration on bioimpedance of thorax and bioimpedance of the whole body in hemodialysed patients. Isovolemic HD was performed during the first hour of dialysis session, using bicarbonate and then acetate dialysate.

Asymptomatic bacteriuria in patients on continuous ambulatory peritoneal dialysis.

Unlabelled: Chronic inflammatory state and chronic infections appear to be one of the most important risk factors of morbidity and mortality in patients (pts) on dialysis. The aim of our study was to determine the frequency of urinary tract infections (UTI) in clinically asymptomatic patients on CAPD. The study included 43 (22F, 21M) clinically stable asymptomatic CAPD patients with diuresis ranged from 300 to 2500 ml per 24 h.