Curated benchmark dataset for ultrasound based breast lesion analysis.

A new detailed dataset of breast ultrasound scans (BrEaST) containing images of benign and malignant lesions as well as normal tissue examples, is presented. The dataset consists of 256 breast scans collected from 256 patients. Each scan was manually annotated and labeled by a radiologist experienced in breast ultrasound examination.

Enhanced biological activity of liposomal methylated resveratrol analog 3'-hydroxy-3,4,5,4'-tetramethoxystilbene (DMU-214) in 3D patient-derived ovarian cancer model.

3'-hydroxy-3,4,5,4'-tetramethoxystilbene (DMU-214) belongs to methoxystilbenes family and is an active metabolite of 3,4,5,4'-tetramethoxystilbene (DMU-212). In several of our previous studies, the anti-apoptotic activity of DMU-214 was significantly higher than that of the parent compound, especially in ovarian cancer cells. Due to increased lipophilicity and limited solubility, methoxystilbenes require a solubilization strategy enabling DMU-214 administration to the aqueous environment.

Joint segmentation and classification of breast masses based on ultrasound radio-frequency data and convolutional neural networks.

In this paper, we propose a novel deep learning method for joint classification and segmentation of breast masses based on radio-frequency (RF) ultrasound (US) data. In comparison to commonly used classification and segmentation techniques, utilizing B-mode US images, we train the network with RF data (data before envelope detection and dynamic compression), which are considered to include more information on tissue's physical properties than standard B-mode US images. Our multi-task network, based on the Y-Net architecture, can effectively process large matrices of RF data by mixing 1D and 2D convolutional filters.

Comparison of the radial and brachial artery flow-mediated dilation in patients with hypertension.

Background: Blood flow-mediated dilation (FMD) is a noninvasive assessment of vascular endothelial function in humans. The study of the FMD in hypertensive (HT) patients is an important factor supporting the recognition of the early mechanisms of cardiovascular pathologies, and also of the pathogenesis related to hypertension.

Objectives: To investigate whether FMD measured on the radial artery (FMD-RA) using high-frequency ultrasounds can be used as an alternative to FMD assessed with the lower frequency system on the brachial artery in patients with HT.

Ovarian Cancer and Cancer Stem Cells-Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology.

Despite the increasing development of medicine, ovarian cancer is still a high-risk, metastatic disease that is often diagnosed at a late stage. In addition, difficulties in its treatment are associated with high resistance to chemotherapy and frequent relapse. Cancer stem cells (CSCs), recently attracting significant scientific interest, are considered to be responsible for the malignant features of tumors.

DOES FLOW-MEDIATED DILATION NORMALIZATION FOR BASE-SCALED SHEAR RATE IMPROVE ITS VALUE IN CORONARY ARTERY DISEASE DIAGNOSTICS?

The article presents a new normalization of flow-mediated dilation (FMD) in the radial artery, taking into account the parameter BSSR being equal to the ratio of the basal shear rate (BS) measured before the cuff inflation and post occlusive shear rate (SR). The in vivo usefulness of the new normalization algorithm was evaluated in two groups of patients. In group I, comprising 15 healthy volunteers, the normalized FMD/SR was (3.

Safety of ultrasonic examinations; thermal and mechanical indices.

This review article combines the reports on the biophysical effects in ultrasonography and provides the rationale behind the mechanical index (MI) and thermal index (TI) complying with the Output Display Standard (ODS). Safe ultrasonic doses are determined according to specific rules, and the screen displays the associated quantities MI and TI. The introduced indices MI and TI take into account the physical mechanism of interaction between ultrasounds and biological tissue, which depends on the temporal and spatial parameters of the acoustic field generated by ultrasound transducers.

The Effect of 4'-hydroxy-3,4,5-trimetoxystilbene, the Metabolite of Resveratrol Analogue DMU-212, on Growth, Cell Cycle and Apoptosis in DLD-1 and LOVO Colon Cancer Cell Lines.

Resveratrol is a phytoalexin that naturally occurs in grapes, blueberries, cranberries, peanuts and many other plants. Although resveratrol inhibits carcinogenesis in all three stages, its clinical application is restricted due to poor pharmacokinetics. The methylated analogues of resveratrol have been found to have higher bioavailability and cytotoxic activity than that of the prototupe compound.

The Effect of 3'-Hydroxy-3,4,5,4'-Tetramethoxy -stilbene, the Metabolite of the Resveratrol Analogue DMU-212, on the Motility and Proliferation of Ovarian Cancer Cells.

Targeting tumor cell motility and proliferation is an extremely important challenge in the prevention of metastasis and improving the effectiveness of cancer treatment. We recently published data revealing that DMU-214, the metabolite of firmly cytotoxic resveratrol analogue DMU-212, exerted significantly higher biological activity than the parent compound in ovarian cancer cells. The aim of the present study was to assess the molecular mechanism of the potential anti-migration and anti-proliferative effect of DMU-214 in ovarian cancer cell line SKOV-3.

Sense of coherence and acceptance of the disease in patients with lung cancer during palliative chemotherapy.

Introduction: An important part of the therapeutic process of patients with lung cancer undergoing palliative chemotherapy is to assess their mental well-being. Evaluation of the sense of coherence and acceptance of the disease, which reflects the degree of adaptation of the patient to live with the disease, provides information on this topic.

Objective: The primary objective was to assess the level of sense of coherence and acceptance of the disease in patients with lung cancer during palliative chemotherapy as well as coherence and acceptance together with socio-demographic factors.

Clinical value of colonoscopy and positron emission tomography with computed tomography for colorectal cancer diagnosis.

Introduction: Colonoscopy and PET / CT are among the major diagnostic tests for colorectal cancer. The sensitivity, specificity, and accuracy of these studies are still being assessed differently.

Objective: The aim of the study was to compare the sensitivity, specificity and accuracy of colonoscopy and PET / CT in the diagnosis of colorectal cancer.

Incidence, morbidity and 5-year survival of colorectal cancer patients in the Kujawsko-Pomorskie voivodship in 2005-2011, based on data from the National Health Fund.

Introduction: The incidence, morbidity and 5-year survival rates illustrate the epidemiological situation of colorectal cancer and assess the effectiveness of the treatment. In Poland, the National Health Fund is the payer of benefits. The data related to morbidity, incidence, and 5-year survival may be supplementary to the epidemiological data of the National Cancer Registry.

Transfer learning with deep convolutional neural network for liver steatosis assessment in ultrasound images.

Purpose: The nonalcoholic fatty liver disease is the most common liver abnormality. Up to date, liver biopsy is the reference standard for direct liver steatosis quantification in hepatic tissue samples. In this paper we propose a neural network-based approach for nonalcoholic fatty liver disease assessment in ultrasound.

Barrett's esophagus and gland cancer - the experience of one center.

Objective: The aim of the study was to evaluate the prevalence and clinical aspects of Barrett's esophagus and adenocarcinoma of the lower part of esophagus in gastroscopy.

Material And Methods: Retrospective review of 10000 upper gastrointestinal endoscopic examinations were performed at the Department of Oncology Endoscopy in Bydgoszcz from 2004 to 2014 in terms of incidence of Barrett's esophagus and adenocarcinoma in the lower part of esophagus.

Results: The medical records of 5378 (53.

Detecting cerebrovascular changes in the brain caused by hypertension in atrial fibrillation group using acoustocerebrography.

Acoustocerebrography is a novel, non-invasive, transcranial ultrasonic diagnostic method based on the transmission of multispectral ultrasound signals propagating through the brain tissue. Dedicated signal processing enables the estimation of absorption coefficient, frequency-dependent attenuation, speed of sound and tissue elasticity. Hypertension and atrial fibrillation are well known factors correlated with white matter lesions, intracerebral hemorrhage and cryptogenic stroke numbers.

20-MHz Ultrasound for Measurements of Flow-Mediated Dilation and Shear Rate in the Radial Artery.

A high-frequency scanning system consisting of a 20-MHz linear array transducer combined with a 20-MHz pulsed Doppler probe was introduced to evaluate the degree of radial artery flow-mediated dilation (FMD [%]) in two groups of patients after 5 min of controlled forearm ischemia followed by reactive hyperemia. In group I, comprising 27 healthy volunteers, FMD (mean ± standard deviation) was 15.26 ± 4.

The acceptance of illness in lung cancer patients before and after surgical treatment.

Unlabelled: Lung cancer is the most common malignant tumor in the world, as well as one of the cancers with the most fatal prognosis. The acceptance of the disease is the most important element of the adaptive process. The better the illness acceptance, the lower the stress level and the higher the self-esteem, which facilitates the adaptation to the health status.

Open access database of raw ultrasonic signals acquired from malignant and benign breast lesions.

Purpose: The aim of this paper is to provide access to a database consisting of the raw radio-frequency ultrasonic echoes acquired from malignant and benign breast lesions. The database is freely available for study and signal analysis.

Acquisition And Validation Methods: The ultrasonic radio-frequency echoes were recorded from breast focal lesions of patients of the Institute of Oncology in Warsaw.

[Acceptance of the disease and tendency to pay higher health insurance fee by patients with lung cancer].

Introduction: Thanks to knowledge on the relationship between acceptance of disease and the willingness to co-pay for treatment in patients with lung cancer we can try to assess whether their introduction would be justified and acceptable.

The Aim: The purpose of the study was to examine the propensity of patients with lung cancer to pay higher rate of health insurance depending on their acceptance of the disease.

Materials And Methods: The study was conducted in 2016 at the Oncology Center in Bydgoszcz and the Kujawsko-Pomorskie Pulmonology Center in Bydgoszcz.

The assessment of cancer-related fatigue syndrome in patients with lung cancer during palliative chemotherapy.

Introduction: Cancer-related fatigue is one of the most common problems of patients with lung cancer. The assessment of cancer- -related fatigue is therefore a significant medical problem in patients during treatment with palliative chemotherapy.

Material And Methods: The study included 100 patients during palliative chemotherapy because of lung cancer.

In vitro ultrasound experiments: Standing wave and multiple reflections influence on the outcome.

The purpose of this work was to determine the influence of standing waves and possible multiple reflections under the conditions often encountered in examining the effects of ultrasound exposure on the cell cultures in vitro. More specifically, the goal was to quantitatively ascertain the influence of ultrasound exposure under free field (FF) and standing waves (SW) and multiple reflections (MR) conditions (SWMR) on the biological endpoint (50% cell necrosis). Such information would help in designing the experiments, in which the geometry of the container with biological tissue may prevent FF conditions to be established and in which the ultrasound generated temperature elevation is undesirable.

Annular phased array transducer for preclinical testing of anti-cancer drug efficacy on small animals.

A technique using pulsed High Intensity Focused Ultrasound (HIFU) to destroy deep-seated solid tumors is a promising noninvasive therapeutic approach. A main purpose of this study was to design and test a HIFU transducer suitable for preclinical studies of efficacy of tested, anti-cancer drugs, activated by HIFU beams, in the treatment of a variety of solid tumors implanted to various organs of small animals at the depth of the order of 1-2cm under the skin. To allow focusing of the beam, generated by such transducer, within treated tissue at different depths, a spherical, 2-MHz, 29-mm diameter annular phased array transducer was designed and built.

Classification of breast lesions using segmented quantitative ultrasound maps of homodyned K distribution parameters.

Purpose: Statistical modeling of an ultrasound backscattered echo envelope is used for tissue characterization. However, in the presence of complex structures within the analyzed area, estimation of parameters is disturbed and unreliable, e.g.

Introduction to ultrasound elastography.

For centuries tissue palpation has been an important diagnostic tool. During palpation, tumors are felt as tissues harder than the surrounding tissues. The significance of palpation is related to the relationship between mechanical properties of different tissue lesions.

Tissue Attenuation Estimation by Mean Frequency Downshift and Bandwidth Limitation.

Attenuation of ultrasound in tissue can be estimated from the propagating pulse center frequency downshift. This method assumes that the envelope of the emitted pulse can be approximated by a Gaussian function and that the attenuation linearly depends on frequency. The resulting downshift of the mean frequency depends not only on attenuation but also on pulse bandwidth and propagation distance.