Treatment with bestatin (the exogenous synthetic inhibitor of metalloproteinases) reduces the activity of metalloproteinase 2 and 12 in the spleen and lung tissues of rats in a model of lipopolysaccharide-induced sepsis.

Sepsis is caused by an inadequate or dysregulated host response to infection. Enzymes causing cellular degradation are matrix metalloproteinases (MMPs). Lipopolysaccharide (LPS) is used in models of sepsis in laboratory settings The aim of the study was to measure MMP 2 and 12 concentrations in spleen and lungs in rats in which septic shock was induced by LPS.

Interleukin 1α and interleukin 18 in patients with vitiligo - Results of a case-control study.

Introduction: Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. Variety of inflammatory mediators participate in the regulation of melanogenesis in melanocytes: interleukin-18 (IL-18), interleukin-33, granulocyte-macrophage colony stimulating factor, interferon-γ, prostaglandin E2 have the effect of promoting melanogenesis, while interleukin-1 (IL-1), interleukin-4, interleukin-6, interleukin-17 and tumor necrosis factor can inhibit melanogenesis.

Aim: Evaluation of IL-1α and IL-18 levels in peripheral blood in patients with vitiligo compared to healthy controls.

A case-control study on immunologic markers of patients with vitiligo.

Vitiligo is a depigmentation skin disease often coexisting with other autoimmune disorders. The prevalence is 0.5-2 % of the world's population.

Lipoic acid (LA) dose-dependently protects bone losses in the mandible of rats during the development of osteopenia by inhibiting oxidative stress and promoting bone formation.

Our study was carried out to evaluate the effect of lipoic acid (LA) on the densitometric properties, structure and mechanical strength of the mandible of Wistar rats with developing osteopenia. The study used 42 sham-operated (SHO) and ovariectomized (OVX) rats. The OVX rats were randomly divided (n = 6) onto two controls treated subcutaneously with physiological saline (OVX-PhS) and 17β-estradiol (OVX-E2), respectively, and onto four experimental OVX groups that received LA in the doses of 12.

Prolonged exposure to transdermal nicotine improves memory in male mice, but impairs biochemical parameters in male and female mice.

Introduction: Nicotine is an alkaloid that affects the functioning of the central nervous system and produces dependence. In low doses, it acts as a stimulant and relaxant. Nicotine was reported to have pro-cognitive effects in humans and animals.

Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis.

Objective: Psoriasis and depression may have common mechanisms, such as systemic inflammation, dysfunction of the hypothalamic-pituitary-adrenal axis, and vitamin D3 deficiency. Among men with psoriasis, this study examined whether depression severity was associated with serum concentrations of different metabolic and inflammatory markers.

Methods: The study included 85 men with psoriasis (mean age ± standard deviation [SD], 47 ± 14 years) and 65 men without psoriasis (mean age ± SD, 44 ± 13 years).

Correction to: Digestive system in psoriasis: an update.

In the original publication, the data labels are incorrect in Fig. 3. The corrected Fig.

Digestive system in psoriasis: an update.

Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients.

Depressiveness, measured with Beck Depression Inventory, in patients with psoriasis.

Background: The aim of this study was to identify demographic and clinical factors predisposing to depressiveness during the course of psoriasis.

Method: The study included 239 patients with psoriasis (15-76 years, 31.8% of women) and 123 healthy controls (17-74 years, 32.

The 28-day exposure to fenpropathrin decreases locomotor activity and reduces activity of antioxidant enzymes in mice brains.

Background: Fenpropathrin (Fen) is a pyrethroid (Pyr) insecticide. Pyrs are used in veterinary medicine, in agriculture and for domestic purposes. As their use increases, new questions about their side effects and mode of action in non-target organisms arise.

Subacute poisoning of mice with deltamethrin produces memory impairment, reduced locomotor activity, liver damage and changes in blood morphology in the mechanism of oxidative stress.

Background: Deltamethrin (DEL) is a synthetic pyrethroid (PYR) insecticide, potent neurotoxicant. The current investigation was envisaged to explore behavioral, biochemical and morphologic effects of subacute poisoning with DEL in mice and to find one common mechanism of these changes.

Methods: Mice were daily injected ip with different doses of DEL: 8.

Effect of lambda-cyhalothrin on memory and movement in mice after transient incomplete cerebral ischemia.

Lambda-cyhalothrin (LCH) is a synthetic pyrethroid used as an insecticide. The aim of the study was to investigate the effect of LCH on memory, movement activity, and co-ordination in mice exposed to bilateral clamping of the carotid arteries (BCCA). On the first postsurgical day, the examined animals (BCCA/LCH) were injected with LCH i.

Influence of fenpropathrin on memory and movement in mice after transient incomplete cerebral ischemia.

Fenpropathrin, a synthetic pyrethroid widely used as an insecticide, is known to affect locomotion and memory in mammals. It is possible that exposure to pyrethroids may occur in an elderly population where transient ischemic attacks are a higher risk for occurrence with consequent changes in memory and control of movement. Thus, the aim of this study was to determine whether bilateral clamping of carotid arteries (BCCA), a model for ischemia, together with fenpropathrin affected memory in tests such as the passive avoidance task and fresh spatial memory in a Y-maze, as well as movement activity and movement coordination on a rotarod in mice.

The influence of intracerebral streptozotocin and/or cadmium on memory processes in mice exposed to transient cerebral oligemia.

The aim of the study was to examine the effects of simultaneous acute exposure to cadmium (Cd) and in the presence of streptozotozin (STZ) on the central nervous system (CNS) memory processes in mice subjected to transient brain ischemia. In order to obtain transient brain ischemia, operative occlusion of common carotid arteries for 30 min was performed. Cadmium chloride was administered intraperitoneally (ip) after the surgery at a single dose of 0.

Influence of the zearalenone on the activity of chosen liver enzymes in a rat.

Zearalenone is a mycotoxin compound produced mainly by Fusarium species of fungi which is present in cereals cultivated all over the world. The aim of the research was to examine the toxic influence of different doses of zearalenone on liver cells through estimating mycotoxin influence on markers evaluation of biochemical liver damage. The research was carried out on male Wistar rats.

[Smoking among patients hospitalized in SPSK 4 in Lublin].

Approximately 10 mln of Poles smoke 15-20 cigarettes per day. In total Poles smoke 4,5 billions of packaging each year. Nicotine is not only major threat to humans' health but smoking is also one of the most common elements of any healthy life style.

Loss of heterozygosity for Rb locus and pRb immunostaining in laryngeal cancer: a clinicopathologic, molecular and immunohistochemical study.

Several risk factors for the development of laryngeal cancer have been identified, such as smoking and alcohol consumption, but the molecular mechanisms related to the carcinogenesis in the larynx remain under investigation. In this context, deregulations of the cell-cycle-controling mechanisms, Rb-pathway in particular, have been suggested to be involved in the pathogenesis of laryngeal carcinoma. Our purpose was to investigate 13q14 LOH and the expression of Rb protein and their possible prognostic value in laryngeal cancer.

[Impact of cigarette smoking on the clinical outcome of Crohn's disease].

Cigarette smoking is a well known independent risk factor for a more severe course of Crohn's disease, but individual factors determining this impact are poorly known and it is not evident if smoking cessation is associated with an improvement in the disease activity. The aim of our study was to assess the factors determining the harmful impact of smoking in individuals with Crohn's disease. A total of 148 consecutive patients with Crohn's disease and Crohn's disease activity index < 200 were enrolled in a prospective 12-18 month study.

Effect of cypermethrin on memory, movement activity and coordination in mice after transient incomplete cerebral ischemia.

Cypermethrin is a synthetic pyrethroid widely used as an insecticide. The aim of the present study was to investigate the possible effect of 0.1 LD50 of cypermethrin on memory, movement activity and co-ordination in mice exposed to transient incomplete cerebral ischemia.

[Tobacco smoking among adolescents-self-reported psycho-somatic health].

Studies of self-reported psychosomatic health among non-smokers and current smokers were conducted among students aged 19-20 by means of a standardised questionnaire form concerning people actively and passively smoking. The analysis covered the number and type of cigarettes, time of exposure to tobacco smoke, as well as health effects in active and passive smokers. Tobacco smokers constituted 22% of the total number of the population examined, whereas passive smokers - 78%.

[Addiction among patients hospitalized due to peripheral vessels disorders].

The study covered 160 patients - 80 females and 80 males, hospitalised due to arterial and venous vessels disorders. The objective of the study was an attempt to evaluate selected behaviours, such as tobacco smoking, consumption of alcohol and coffee among people with diseases of peripheral vessels. The research tool was a questionnaire form.

[Calcium concentration in the skin of male rats exposed to high doses of ochratoxin A (OTA)].

Background: Ochratoxin A (OTA) is one of mycotoxines that most frequently creates occupational hazards. The aim of the study was to observe calcium concentration in the skin of test animals exposed to high doses of ochratoxin A (OTA).

Materials And Methods: Tests were carried out in two groups of male rats exposed to high doses of OTA (1 mg/kg(-1)) for 30 days.

Nutritional assessment and eating habits analysis in young adults.

Good eating habit is an essential part of a healthy lifestyle. It helps prevent civilisation diseases. The BMI and eating plan analysis are useful in individual's nutritional assessment.

Hazard estimation for the chosen work stands in metallurgical industry.

The research has been carried out on the chosen work stands of various strenuousness level in metallurgical industry. Microclimate conditions were estimated, together with noise exposure, dust density and the exposure to the chosen chemical agents, among others carbon monoxide, nitric oxides, manganese and iron. The analysis of the resulting figures showed exceeding of the binding quotas of Wet Bulb Globe Temperature (WBGT) indicator for some stands, leading sometimes to thermal discomfort.

The influence of sex hormones and vitamin E on ascorbic acid concentration in rat tissues.

Ascorbic acid concentration in a living body undergoes alterations continually. The changes in homeostasis of this important antioxidant may be induced by the effect of sex hormones for example. Based on this, the aim of our work was to estimate the influence of sex hormones administration and vitamin E supplementation on tissue ascorbic acid concentration in female and male rats.