Publications by authors named "Andrii S Myshko"
Article Synopsis
- A new method was created to trap certain chemical intermediates (benzopyrone-based ortho-quinone methides) using 3- and 5-amino pyrazoles or isoxazoles.
- Various hybrid compounds were synthesized from natural phenolic Mannich bases and flavonoids, such as coumarin and isoflavone, with moderate to good yields depending on the position of the amino group.
- Some of the resulting compounds, especially those with 5-aminoisoxazole, showed the ability to inhibit α-glucosidase, demonstrating potential biological activity with micromolar IC values.
An efficient green approach for the trapping of generated -and -quinone methide intermediates by imidazoles and pyrazoles has been developed. A wide range of quinone methide precursors based on simple phenols are compatible with the experimental protocol under mild thermal conditions. This methodology was demonstrated to be suitable for the synthesis of methylene-linked benzopyrone-azole hybrids using naturally occurring coumarin and chromone Mannich bases.
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