Creating a digital approach for promoting physical activity in pediatric pulmonary hypertension: A framework for future interventions.

Children with pulmonary hypertension (PH) often demonstrate limited exercise capacity. Data support exercise as an effective nonpharmacologic intervention among adults with PH. However, data on exercise training in children and adolescents are limited, and characteristics of the optimal exercise program in pediatric PH have not been identified.

Glucono-Delta-Lactone-Induced Alginate Gelation: New Insights into the Effect of the Cross-Linker Carrier Type on the Hydrogel Mechanics.

Physical alginate hydrogels commonly rely on "internal gelation" to introduce the cross-linker, e.g., calcium (Ca(II)) ions.

Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational retrospective cohort SOPHIA study.

Background: Weight loss trajectories after bariatric surgery vary widely between individuals, and predicting weight loss before the operation remains challenging. We aimed to develop a model using machine learning to provide individual preoperative prediction of 5-year weight loss trajectories after surgery.

Methods: In this multinational retrospective observational study we enrolled adult participants (aged ≥18 years) from ten prospective cohorts (including ABOS [NCT01129297], BAREVAL [NCT02310178], the Swedish Obese Subjects study, and a large cohort from the Dutch Obesity Clinic [Nederlandse Obesitas Kliniek]) and two randomised trials (SleevePass [NCT00793143] and SM-BOSS [NCT00356213]) in Europe, the Americas, and Asia, with a 5 year follow-up after Roux-en-Y gastric bypass, sleeve gastrectomy, or gastric band.

One-Step Generation of Alginate-Based Hydrogel Foams Using CO for Simultaneous Foaming and Gelation.

The reliable generation of hydrogel foams remains a challenge in a wide range of sectors, including food, cosmetic, agricultural, and medical applications. Using the example of calcium alginate foams, we introduce a novel foam generation method that uses CO for the simultaneous foaming and pH reduction of the alginate solution to trigger gelation. We show that gelled foams of different gas fractions can be generated in a simple one-step process.

Investigating Pore-Opening of Hydrogel Foams at the Scale of Freestanding Thin Films.

Controlling the pore connectivity of polymer foams is key for most of their applications, ranging from liquid uptake, mechanics, and acoustic/thermal insulation to tissue engineering. Despite their importance, the scientific phenomena governing the pore-opening processes remain poorly understood, requiring tedious trial-and-error procedures for property optimization. This lack of understanding is partly explained by the high complexity of the different interrelated, multiscale processes which take place as the foam transforms from an initially fluid foam into a solid foam.

PoreScript: Semi-automated pore size algorithm for scaffold characterization.

The scaffold pore size influences many critical physical aspects of tissue engineering, including tissue infiltration, biodegradation rate, and mechanical properties. Manual measurements of pore sizes from scanning electron micrographs using ImageJ/FIJI are commonly used to characterize scaffolds, but these methods are both time-consuming and subject to user bias. Current semi-automated analysis tools are limited by a lack of accessibility or limited sample size in their verification process.

Hydrogel foams from liquid foam templates: Properties and optimisation.

Hydrogel foams are an important sub-class of macroporous hydrogels. They are commonly obtained by integrating closely-packed gas bubbles of 10-1000 μm into a continuous hydrogel network, leading to gas volume fractions of more than 70% in the wet state and close to 100% in the dried state. The resulting wet or dried three-dimensional architectures provide hydrogel foams with a wide range of useful properties, including very low densities, excellent absorption properties, a large surface-to-volume ratio or tuneable mechanical properties.

Microfluidic thin film pressure balance for the study of complex thin films.

Investigations of free-standing liquid films enjoy an increasing popularity due to their relevance for many fundamental and applied scientific problems. They constitute soap bubbles and foams, serve as membranes for gas transport or as model membranes in biophysics. More generally, they provide a convenient tool for the investigation of numerous fundamental questions related to interface- and confinement-driven effects in soft matter science.

"I Want to Lose Weight and it Has to Be Fair": Predictors of Satisfaction After Bariatric Surgery.

Purpose: Bariatric surgery (BS) is the most effective technique used to help patients with obesity achieve long-term weight loss. Although many patients report high levels of postoperative satisfaction after BS, some remain unsatisfied with their outcome. Studies of factors that predict postoperative satisfaction have yielded varying results.

Liquid foam templating - A route to tailor-made polymer foams.

Solid foams with pore sizes between a few micrometres and a few millimetres are heavily exploited in a wide range of established and emerging applications. While the optimisation of foam applications requires a fine control over their structural properties (pore size distribution, pore opening, foam density, …), the great complexity of most foaming processes still defies a sound scientific understanding and therefore explicit control and prediction of these parameters. We therefore need to improve our understanding of existing processes and also develop new fabrication routes which we understand and which we can exploit to tailor-make new porous materials.

Generation of Solid Foams with Controlled Polydispersity Using Microfluidics.

Many properties of solid foams depend on the distribution of the pore sizes and their organization in space. However, these two parameters are very difficult to control with most traditional foaming techniques. Here we show how microfluidics can be used to tune the polydispersity of the foams (mono- vs different polydispersities) and the spatial organization of the pores (ordered vs disordered).

Impact of emotional awareness and parental bonding on emotional eating in obese women.

This study aimed to: (1) determine whether obese women have deficits in emotional awareness and more frequently use emotional eating to regulate their emotions, (2) assess the impact of emotional awareness on the use of emotional eating, and (3) explore the impact of parental bonding on patient level of emotional awareness. A sample of 94 obese women was compared with 56 control participants. All participants answered questionnaires concerning their eating habits (Dutch Emotional Behavior Questionnaire), emotional awareness (Level of Emotional Awareness Scale) and parental bonding (Parental Bonding Inventory).

Risk of biliary complications in bariatric surgery.

Gallstones are commonly observed after rapid weight loss, particularly after bariatric surgery. Preventive measures of gallstone formation and potential related complications are still debated. This study aimed to propose a standardized strategy according to the results of the literature.

The effect of opioids and their antagonists on the nocifensive response of Caenorhabditis elegans to noxious thermal stimuli.

Opiates modulate nociception in vertebrates. This has also been demonstrated in a number of invertebrate models. Herein, the effect of the opiate morphine and opioid neuropeptides Endomorphin 1 and 2 on the thermal avoidance (Tav) behavior of Caenorhabditis elegans is explored.

Lingual thyroid. A case report.

We describe an unusual clinical case in which a non functional cervical thyroid coexisted with a functional ectopic lingual thyroid. A twenty-year-old woman was referred for hypothyroidism treated with L-thyroxin related to a basilingual tumor diagnosed 8 years previously. Oropharyngeal examination showed a spherical basilingual tumor 2.