The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin.

Cucurbit[7]uril (CB[7]) is a molecular container that may form host-guest complexes with platinum(II) anticancer drugs and modulate their efficacy and safety. In this paper, we report our studies of the effect of CB[7]-oxaliplatin complex and the mixture of CB[7] and carboplatin (1:1) on viability and proliferation of a primary cell culture (peripheral blood mononuclear cells), two tumor cell lines (B16 and K562) and their activity in the animal model of melanoma. At the same time, we studied the impact of platinum (II) drugs with CB[7] on T cells and B cells in vitro.

[The prolonged intraarterial medicinal therapy of the destructive forms of diabetic foot syndrome].

The results of surgical treatment of 76 patients. suffering diabetes mellitus with purulent--necrotic affection of the foot. were analyzed.

[Ways of improvement in surgical treatment of purulent-necrotic complications in the diabetic foot syndrome].

Results of surgical treatment of 168 patients with diabetes mellitus (DM) in the diabetic foot syndrome (DFS) were analyzed. Expediency of operative intervention was substantiated by pathogenic form of affection, its depth and diffusion, composition of microorganisms in purulent-necrotic focus. Performance of more extensive surgical treatment or distal amputation of foot with consequent closure of vast wound defect using full-layer subcutaneous-cutaneous flap with protracted selective intra-arterial anti-aggregate and antibacterial therapy was indicated in order to preserve the lower extremity supporting function and for prophylaxis of diffusion of purulent-necrotic affection.

[Forlax in the treatment of chronic constipation of different origins].

The greatest benefit from forlax occurs in patients with constipation of various etiology. The highest effect was recordable in those patients with functional pathology of the intestinal tract who experienced increased frequency of their stools and alleviation of clinical manifestations of the illness to the greatest degree. In patients with decompensated cirrhosis normalization of stool was accompanied by a significant improvement in general condition and what is more, clinical manifestations of portal-systemic encephalopathy tended to be less pronounced.

[Diagnosis of acute intestinal obstruction].

The results of treatment of 182 patients with an acute ileus were analyzed. While roentgenography conduction the characteristical signs of the disease were noted in 68.7% of patients and in 31.

[The effect of the professional activities of flight personnel on their tolerance for the rebreathing test].

The return breathing test (rerespiration) developed by the authors makes it possible to conduct testing on the efficiency of compensatory reactions and disclose the reserve capacities of cardiorespiratory system in pilots. 82 pilots were examined in the process of their professional activity. The major part can be subdivided into 3 groups with middle, good and high tolerance to rerespiration, having 1/3 of pilots under 30 years old a high tolerance to test.

[The metastasis of cancer of the extrahepatic bile ducts].

The pathoanatomical investigations results in 105 patients with extrahepatic biliary ducts cancer are presented. The organotropism and the lymphotropic metastatic spreading predominance are revealed. The most frequently involved are the lymph nodes (73.

[Detoxication methods in pancreatogenic enzymatic peritonitis].

A therapeutic response was analyzed in 536 patients with acute destructive pancreatitis complicated by pancreatogenic enzymatic peritonitis. All the patients had the syndrome of endogenic intoxication and underwent intensive resuscitation with protease inhibitors, cytostatic agents, antibacterial, desensitization and detoxication treatment. If indicated, the patients with pronounced endogenic intoxication were subjected to forced diuresis, abdominal laparoscopic drainage and intraperitoneal dialysis, drainage of the thoracic lymphatic duct, hemosorption.

[Informative value of rerespiration as a method for evaluating functional reserves of the cardiorespiratory system in modeling of some flight factors].

This article presents a study of the informative value of the recurrent breathing (rerespiration) method developed by the authors, for evaluating the functional status of the human body during recovery after exposure to noise and vibration, to piloting accelerations and head-down hypokinesis. It is shown that a 1.5-h exposure to noise and vibration increases tolerance to rerespiration, suggesting a stimulatory effect.

[The use of ultraviolet-irradiated blood reinfusion in the combined treatment of destructive pancreatitis].

The results of treatment of the patients with acute destructive pancreatitis who in the complex underwent reinfusion of the blood irradiated with ultra-violet rays were analysed. The given method permitted to improve the results of treatment, as it was witnessed by rapid decrease in intoxication, normalization of clinical and laboratory indices. The lethality reduced by 1.

[Criteria of tolerance of the hypercapnia-hypoxia test].

Examination of 84 essentially healthy men, aged 19 to 34 years, by the rebreathing method showed that in various test subjects the reserve time prior to decompensation was in the range 5 to 9 min. A certain change was seen 1-2 min before termination of the test due to acute respiratory failure. This change included an increase in the minute respiration volume above 40 1/min and its relative increment by 10 1/min or over when compared to the preceding minute.