Publications by authors named "Andria Langenberg"
A plain language summary of the safety of relugolix combination therapy and improvement in symptoms in women with uterine fibroids from the LIBERTY 1 and LIBERTY 2 studies.
Pain Manag
April 2023
Article Synopsis
- The LIBERTY 1 and LIBERTY 2 studies evaluated the effectiveness of relugolix combination therapy in reducing heavy menstrual bleeding in women with uterine fibroids compared to a placebo.
- Approximately 73% of women in LIBERTY 1 and 71% in LIBERTY 2 experienced significant reductions in menstrual blood loss after 24 weeks of treatment.
- Common side effects included headaches and hot flushes, but overall, the side effects were comparable among the treatment and placebo groups.
Article Synopsis
- Uterine fibroids cause significant menstrual bleeding and pain, and a new treatment approach using relugolix combined with estradiol and norethindrone acetate may offer a solution without lowering estrogen levels.
- In two international phase 3 trials, women were randomized to receive either the relugolix combination therapy, placebo, or delayed therapy, with the main goal being to see how many had reduced menstrual blood loss and related symptoms.
- Results showed that 71-73% of women on the combination therapy reported improvement, compared to only 15-19% in the placebo group, with additional benefits seen across several secondary measures, highlighting the efficacy of this treatment for managing symptoms related to uterine fibroids.
Background: The degree of effectiveness of condom use in preventing the transmission of herpes simplex virus 2 (HSV-2) is uncertain. To address this issue, we performed a large pooled analysis.
Methods: We identified prospective studies with individual-level condom use data and laboratory-defined HSV-2 acquisition.
We propose that the remodeling process that occurs in localized areas on endosteal bone surfaces and in Haversian canals shares many features in common with the mammalian hair cycle. In both, there are phases of resorption or regeneration, a transition phase, and then a phase of growth, termed anagen in the hair follicle, and formation in the bone remodeling cycle. Furthermore, we suggest that these processes both use the same molecular mechanisms, and specifically the Hedgehog-BMP-Wnt signal transduction cascades.
View Article and Find Full Text PDFBackground: Few studies have evaluated the relationship between condom use and herpes simplex virus type 2 (HSV-2) and HSV type 1 (HSV-1) acquisition.
Objective: To assess the relationship between condom use and acquisition of HSV-2 and HSV-1 among men and women.
Design: Analysis of data collected as part of a clinical trial of an ineffective candidate vaccine for HSV-2.
Condoms act as mechanical barriers to genital infection. In vitro models demonstrate that condoms are almost impermeable to viruses. A small amount of virus may cross the condom, but the condom can still reduce the level of virus exposure by several orders of magnitude.
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