Statistical Analysis of Microarray Data Clustering using NMF, Spectral Clustering, Kmeans, and GMM.

In unsupervised learning literature, the study of clustering using microarray gene expression datasets has been extensively conducted with nonnegative matrix factorization (NMF), spectral clustering, kmeans, and gaussian mixture model (GMM)are some of the most used methods. However, there is still a limited number of works that utilize statistical analysis to measure the significances of performance differences between these methods. In this paper, statistical analysis of performance differences between ten NMF, six spectral clustering, four GMM, and the standard kmeans algorithms in clustering eleven publicly available microarray gene expression datasets with the number of clusters ranges from two to ten is presented.

Call for a Computer-Aided Cancer Detection and Classification Research Initiative in Oman.

Cancer is a major health problem in Oman. It is reported that cancer incidence in Oman is the second highest after Saudi Arabia among Gulf Cooperation Council countries. Based on GLOBOCAN estimates, Oman is predicted to face an almost two-fold increase in cancer incidence in the period 2008-2020.

Supervised, Unsupervised, and Semi-Supervised Feature Selection: A Review on Gene Selection.

Recently, feature selection and dimensionality reduction have become fundamental tools for many data mining tasks, especially for processing high-dimensional data such as gene expression microarray data. Gene expression microarray data comprises up to hundreds of thousands of features with relatively small sample size. Because learning algorithms usually do not work well with this kind of data, a challenge to reduce the data dimensionality arises.

Nonparametric Tikhonov Regularized NMF and Its Application in Cancer Clustering.

The Tikhonov regularized nonnegative matrix factorization (TNMF) is an NMF objective function that enforces smoothness on the computed solutions, and has been successfully applied to many problem domains including text mining, spectral data analysis, and cancer clustering. There is, however, an issue that is still insufficiently addressed in the development of TNMF algorithms, i.e.