Publications by authors named "Andrey Volnitskiy"
The OCT4 transcription factor is necessary to maintain cell stemness in the early stages of embryogenesis and is involved in the formation of induced pluripotent stem cells, but its role in oncogenesis is not yet entirely clear. In this work, expression was investigated in malignant gliomas. Twenty glioma cell lines and a sample of normal adult brain tissue were used.
View Article and Find Full Text PDFThe potential of standard methods of radiation therapy is limited by the dose that can be safely delivered to the tumor, which could be too low for radical treatment. The dose efficiency can be increased by using radiosensitizers. In this study, we evaluated the sensitizing potential of biocompatible iron oxide nanoparticles coated with a dextran shell in A172 and Gl-Tr glioblastoma cells in vitro.
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- Proton boron capture therapy (PBCT) aims to improve proton therapy's effectiveness by utilizing proton-boron fusion reactions that theoretically increase dose delivery in cancer cells.
- The study investigated the effectiveness of sodium borocaptate (BSH) in enhancing proton radiation's effects on glioma cells, showing only minimal improvement in cell viability and colony formation after treatment.
- Findings suggest that the anticipated benefits of PBCT may not materialize due to the complicated interactions within irradiated tissues, indicating a need for further research into secondary effects rather than just direct dose enhancements.
Extracellular vesicles (EV) are involved in important processes of glioblastoma multiforme (GBM), including malignancy and invasion. EV secreted by glioblastoma cells may cross the hematoencephalic barrier and carry molecular cargo derived from the tumor into the peripheral circulation. Therefore, the determination of the molecular composition of exosomes released by glioblastoma cells seems to be a promising approach for the development of non-invasive methods of the detection of the specific exosomal protein markers in the peripheral blood.
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- The study investigates the interactions of multimeric complexes formed by alpha-lactalbumin and lactoferrin with oleic acid, focusing on their potential pro-apoptotic effects in tumor cells.
- Using small-angle neutron scattering (SANS), the research reveals that alpha-lactalbumin forms complexes with polydisperse oleic acid micelles, while lactoferrin forms a uniform nanoscale particle system.
- Additionally, both complexes appear to influence chromatin structure in isolated nuclei, suggesting their role in exhibiting specific anti-tumor activities.
Malignant transformation is associated with loss of cell differentiation, anaplasia. Transcription factors gli, required for embryonic development, may be involved in this process. We studied the activity of transcription factors gli in high-grade gliomas and their role in maintenance of stem cell state and glioma cell survival.
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