Publications by authors named "Andrey P Prodeus"

Background: Nijmegen breakage syndrome (NBS) is a combined primary immunodeficiency with DNA repair defect, microcephaly, and other phenotypical features. It predominantly occurs in Slavic populations that have a high frequency of carriers with the causative NBN gene c.657_661del5 mutation.

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Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections (LRTIs) in children globally. Predisposing conditions for the development of serious RSV disease include preterm infants and those with cardiopulmonary illness, including congenital heart disease (CHD) and bronchopulmonary dysplasia (BPD). No vaccine is currently approved for the prevention of RSV infection.

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With the active development of molecular-biological science in the last 3-5 years, the complement system became vastly recognized as one of the most important regulators of adaptive immunity. It has been shown that interaction between complement components, included in immune complexes, and complement receptors on a cellular membrane is necessary condition for efficient localization of antigen (Ag) in secondary lymphoid compartment. Transport, trapping and retention of immune complexes on the surface of cells to a large degree depend on functionally active complement system.

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