Publications by authors named "Andrey Bondarev"
Article Synopsis
- Nucleic acid topoisomerases (TOP) are essential enzymes that help manage the structure of DNA and RNA and are targeted in chemotherapy; recent clinical trials reveal a surge in TOP inhibitor investigations.
- The review highlights 233 unique TOP-inhibiting molecules, discussing their current clinical applications, especially in treating bacterial infections and various cancers, while addressing concerns about adverse drug reactions and resistance.
- Ongoing research aims to expand the use of TOP inhibitors to novel indications such as glioblastoma and Clostridium difficile infections, suggesting potential benefits for treating a broader range of infections, including viral and fungal diseases, as new drug classes develop.
Article Synopsis
- - The phosphodiesterase (PDE) enzymes have become important targets for therapy due to their role in regulating signaling pathways, with 87 PDE-inhibiting agents identified, mainly focused on treating chronic obstructive pulmonary disease (COPD), cardiovascular disorders, and inflammatory skin conditions.
- - Current PDE inhibitors, especially those used for COPD, face challenges related to side effects that hinder patient compliance, prompting research into better dosing strategies and the relationship between drug structure and safety.
- - Future research is expected to expand the use of PDE inhibitors to various central nervous system diseases (like schizophrenia and Alzheimer's) and other health conditions, fueled by ongoing clinical and preclinical studies.
Friend or Foe? Revising the Role of Oxygen in the Tribological Performance of Solid Lubricant MoS.
ACS Appl Mater Interfaces
December 2022
Molybdenum disulfide (MoS) is a solid lubricant used in various forms, such as a dry lubricant by itself or as a component of a more complex coating. In both these forms, the effect of oxygen contamination on the sliding properties of the MoS coatings is traditionally considered detrimental, resulting in expensive technological processes to produce pure MoS. Here, it is shown that the high oxygen content does not necessarily hinder the solid lubricant properties and may even result in a lower friction and wear when compared to pure MoS.
View Article and Find Full Text PDFPresowing seed treatment is the first step in growing crops and obtaining a predicted high-quality yield. It plays a vital role in an integrated plant protection system. When treating seeds before sowing, it is crucial to avoid seed damage by the machine working bodies to obtain the planned harvest.
View Article and Find Full Text PDFArticle Synopsis
- Histone deacetylase (HDAC) enzymes are important targets for therapy, with 32 identified HDAC inhibitors largely focused on treating cancer, particularly blood cancers.
- The review highlights recent advancements in HDAC inhibitor clinical trials, indicating a trend toward treating various non-cancer diseases like HIV, muscular dystrophies, and neurodegenerative disorders, including Alzheimer's.
- While combining HDAC inhibitors with other treatments shows potential for improved efficacy, it may also lead to increased side effects, suggesting a growing range of applications for these drugs in clinical development.
Background: The ability of the human body to produce metabolic energy from light modifies fundamental concepts of biochemistry.
Objective: This review discusses the relationships between the long-accepted concept is that glucose has a unique dual role as an energy source and as the main source of carbon chains that are precursors of all organic matter. The capability of melanin to produce energy challenges this premise.
In recent years, bacteria inactivation during their direct physical contact with surface nanotopography has become one of the promising strategies for fighting infection. Contact-killing ability has been reported for several nanostructured surfaces, e.g.
View Article and Find Full Text PDFIntroduction: The G protein-coupled receptors (GPCR) superfamily is among the most widely exploited targets for therapeutics, with drugs mainly targeting the Rhodopsin, Glutamate and Secretin family receptors. The receptors of the Adhesion family, however, remain comparatively unexplored in this aspect. This review aims to discuss the druggability of Adhesion GPCRs (aGPCR), highlighting the relevant opportunities and challenges.
View Article and Find Full Text PDFIntroduction: The use of Dietary Supplements (DS) has increased substantially in the United Arab Emirates (UAE) in recent years, despite the fact that the efficacy and safety of these supplements are not proven yet. In addition, the practices of supplement users in the UAE remain undocumented.
Aim: To determine the usage of DS in health sciences and non-health sciences students; and to determine their knowledge, attitudes and practices (KAP) regarding these supplements.