Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults.

The clusterin () rs11136000 genotype is a probable risk factor for Alzheimer's disease (AD). , also known as the apolipoprotein gene, shares certain properties with the apolipoprotein E () gene with a well-established relationship with AD. This study aimed to determine whether the electrophysiological patterns of brain activation during the letter fluency task (LFT) depend on genotypes in adults without dementia.

Genetic association of apolipoprotein E genotype with EEG alpha rhythm slowing and functional brain network alterations during normal aging.

The ε4 allele of the apolipoprotein E (4+) genotype is a major genetic risk factor for Alzheimer's disease (AD), but the mechanisms underlying its influence remain incompletely understood. The study aimed to investigate the possible effect of the genotype on spontaneous electroencephalogram (EEG) alpha characteristics, resting-state functional MRI (fMRI) connectivity (rsFC) in large brain networks and the interrelation of alpha rhythm and rsFC characteristics in non-demented adults during aging. We examined the EEG alpha subband's relative power, individual alpha peak frequency (IAPF), and fMRI rsFC in non-demented volunteers (age range 26-79 years) stratified by the genotype.

Reduced interhemispheric connectivity in childhood autism detected by electroencephalographic photic driving coherence.

The EEG coherence among 14 scalp points during intermittent photic stimulation at 11 fixed frequencies of 3-24 Hz was studied in 14 boys with autism, aged 6-14 years, with relatively intact verbal and intellectual functions, and 19 normally developing boys. The number of interhemispheric coherent connections pertaining to the 20 highest connections of each individual was significantly lower in autistic patients than in the control group at all the EEG beta frequencies corresponding to those of stimulation. The coefficient of coherence values between homologous occipital, parietal and central areas at the same frequencies were also lower in the autistic group in both mono- and bipolar montages due to a deficit in reactive photic driving increase.

Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults.

The epsilon4 allele of the apolipoprotein E gene (ApoE), as well as aging increase the risk of Alzheimer's and vascular diseases. Electroencephalogram (EEG) reactivity to hyperventilation (HV) depends on hypocapnia-induced cerebral vasoconstriction, which may be impaired in subjects with subclinical cerebrovascular disease. Quantitative EEG at rest and under 3-minute HV was examined in 125 healthy subjects divided into younger (age range 28-50) and older (age range 51-82) cohorts and stratified by ApoE genotype.