Historical myths promote cooperation through affective states.

Although we agree that historical myths function to increase cooperation in the groups that share them, we propose that the mechanisms at work may include affective states. We suggest that sharing historical myths can create a felt sense of intimacy, similarity, and security among group members, which increases trust and motivates cooperation, even without particular beliefs about population structure.

Essential shifts in health workforce measurement: a human-centred approach.

The health sector has faced long-standing challenges in drivers of worker behaviours and performance, such as job satisfaction, which have been worsened by COVID-19. Structural issues including high workloads and poor working conditions have long contributed to dissatisfaction among health workers. The pandemic escalated unsafe working conditions, causing workers' deaths, increasing burnout rates, and contributing to exodus from health-care jobs.

Royal Canadian Mounted Police cadets' exposure to potentially psychologically traumatic events during the Cadet Training Program.

Lifetime exposures to potentially psychologically traumatic events (PPTEs) among Royal Canadian Mounted Police (RCMP) cadets starting the Cadet Training Program (CTP) appear lower than exposures reported by serving RCMP, but the prevalence of PPTE exposures during the CTP remains unknown. The current study assessed PPTE exposures during the CTP and examined associations with mental disorders among RCMP cadets. Participants were cadets (n = 449, 24.

Venipuncture site and population affect blood analytes in head-started and free-ranging eastern box turtles (Terrapene carolina).

Objective: To compare head-started and free-ranging eastern box turtle (Terrapene carolina) blood analytes to evaluate head-starting practices and venipuncture site suitability.

Methods: Eastern box turtles were head-started by Jekyll Island State Park Authority's Georgia Sea Turtle Center. Free-ranging resident box turtles on Jekyll Island State Park were captured.

Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma.

Medulloblastoma (MB) is the most common malignant brain tumour in children. The Sonic Hedgehog (SHH)-medulloblastoma subtype arises from the cerebellar granule neuron lineage. Terminally differentiated neurons are incapable of undergoing further cell division, so an effective treatment for this tumour could be to force neuronal differentiation.

Chemoproteogenomic stratification of the missense variant cysteinome.

Cancer genomes are rife with genetic variants; one key outcome of this variation is widespread gain-of-cysteine mutations. These acquired cysteines can be both driver mutations and sites targeted by precision therapies. However, despite their ubiquity, nearly all acquired cysteines remain unidentified via chemoproteomics; identification is a critical step to enable functional analysis, including assessment of potential druggability and susceptibility to oxidation.

The psychology of rock climbing: A systematic review.

Background: Psychology plays an important role in rock climbing performance and safety. Many studies have examined the psychology of rock climbing, a sport that has grown in popularity and status over the past few decades.

Objective: This systematic review aimed to summarize published research on the psychology of rock climbing, find commonalities and disagreements within the current research and illuminate future research areas.

Machine learning to predict morphology, topography and mechanical properties of sustainable gelatin-based electrospun scaffolds.

Electrospinning is an outstanding manufacturing technique for producing nano-micro-scaled fibrous scaffolds comparable to biological tissues. However, the solvents used are normally hazardous for the health and the environment, which compromises the sustainability of the process and the industrial scaling. This novel study compares different machine learning models to predict how green solvents affect the morphology, topography and mechanical properties of gelatin-based scaffolds.

Discovery of 1,3,4-oxadiazoles with slow-action activity against Plasmodium falciparum malaria parasites.

To achieve malaria eradication, new preventative agents that act differently to front-line treatment drugs are needed. To identify potential chemoprevention starting points we screened a sub-set of the CSIRO Australia Compound Collection for compounds with slow-action in vitro activity against Plasmodium falciparum. This work identified N,N-dialkyl-5-alkylsulfonyl-1,3,4-oxadiazol-2-amines as a new antiplasmodial chemotype (e.

Comparative genomic analysis identifies potential adaptive variation in .

is associated with respiratory disease in wild and domestic Caprinae globally, with wide variation in disease outcomes within and between host species. To gain insight into phylogenetic structure and mechanisms of pathogenicity for this bacterial species, we compared genomes for 99 samples from 6 countries (Australia, Bosnia and Herzegovina, Brazil, China, France and USA) and 4 host species (domestic sheep, domestic goats, bighorn sheep and caribou). Core genome sequences of assemblies from domestic sheep and goats fell into two well-supported phylogenetic clades that are divergent enough to be considered different bacterial species, consistent with each of these two clades having an evolutionary origin in separate host species.

Prevalence and Characterization of Salmonella during Pork Sausage Manufacturing.

Pork carcasses and meat may harbor Salmonella and may contaminate other products during harvest and fabrication. Sources of contamination include manure on hides, environmental contamination, ingredients from external sources, and lymph nodes. Swine lymph nodes are often incorporated into ground meat, as their anatomical location makes removal labor prohibitive.

Sexual victimization among Royal Canadian Mounted Police.

Objective: The present study was designed to provide the first in-depth, academically peer-reviewed assessment of sexual victimization among Royal Canadian Mounted Police (RCMP).

Method: A representative sample of RCMP ( = 1,324; 76.5% men) completed the self-report survey.

Contrasting effect of hybridization on genetic differentiation in three rockfish species with similar life history.

Hybridization can provide evolutionary benefits (e.g., population resilience to climate change) through the introduction of adaptive alleles and increase of genetic diversity.

Online Group Psychotherapy: A Systematic Review.

There is a need within counselling and psychotherapy to ensure their ability to respond to endemic presences such as the COVID-19 pandemic, by utilising rapid technological advances without compromising effectiveness. To do so, existing research about online group therapy must be built upon to provide a comprehensive understanding of the efficacious delivery of this therapy modality. Thus, a systematic review was conducted to collate what is currently known in the published and grey literature on online group therapy, using the PRISMA framework.

Prevalence of current chronic pain in Royal Canadian Mounted Police cadets.

Background: Nearly half of active duty Royal Canadian Mounted Police (RCMP) officers report experiencing current chronic pain (43%; i.e. pain lasting longer than 3 months).

Enzyme-like Acyl Transfer Catalysis in a Bifunctional Organic Cage.

Amide-based organic cage cavities are, in principle, ideal enzyme active site mimics. Yet, cage-promoted organocatalysis has remained elusive, in large part due to synthetic accessibility of robust and functional scaffolds. Herein, we report the acyl transfer catalysis properties of robust, hexaamide cages in organic solvent.

Machine learning to mechanically assess 2D and 3D biomimetic electrospun scaffolds for tissue engineering applications: Between the predictability and the interpretability.

Currently, the use of autografts is the gold standard for the replacement of many damaged biological tissues. However, this practice presents disadvantages that can be mitigated through tissue-engineered implants. The aim of this study is to explore how machine learning can mechanically evaluate 2D and 3D polyvinyl alcohol (PVA) electrospun scaffolds (one twisted filament, 3 twisted filament and 3 twisted/braided filament scaffolds) for their use in different tissue engineering applications.

Exploration of the polymorphic solid-state landscape of an amide-linked organic cage using computation and automation.

Organic cages can possess complex, functionalised cavities that make them promising candidates for synthetic enzyme mimics. Conformationally flexible, chemically robust structures are needed for adaptable guest binding and catalysis, but rapidly exchanging systems are difficult to resolve in solution. Here, we use low-cost calculations and high-throughput crystallisation to identify accessible conformers of a recently reported organic cage by 'locking' them in the solid state.