White matter hyperintensities and hypobaric exposure.

Objective: Demonstrate that occupational exposure to nonhypoxic hypobaria is associated with subcortical white matter hyperintensities (WMHs) on fluid-attenuated inversion recovery magnetic resonance imaging (MRI).

Methods: Eighty-three altitude chamber personnel (PHY), 105 U-2 pilots (U2P), and 148 age- controlled and health-matched doctorate degree controls (DOC) underwent high-resolution MRI. Subcortical WMH burden was quantified as count and volume of subcortical WMH lesions after transformation of images to the Talairach atlas-based stereotactic frame.

OnabotulinumtoxinA successfully used as migraine prophylaxis during pregnancy: a case report.

Botulinum toxin (btx) received U.S. Food and Drug Administration approval for migraine treatment in 2010 with a pregnancy category C.

Hyperintense white matter lesions in 50 high-altitude pilots with neurologic decompression sickness.

Introduction: Neurologic decompression sickness (NDCS) can affect high-altitude pilots, causing variable central nervous system symptoms. Five recent severe episodes prompted further investigation.

Methods: We report the hyperintense white matter (HWM) lesion imaging findings in 50 U-2 pilot volunteers, and compare 12 U-2 pilots who experienced clinical NDCS to 38 U-2 pilots who did not.

Aeromedical decision making and seizure risk after traumatic brain injury: longitudinal outcome.

Introduction: Traumatic brain injury (TBI) is common in young adults and therefore of significant concern to an aircrew population. This paper reports the occurrences of seizures in U.S.