With the goal of studying skin wound healing and testing new drug treatments to enhance wound healing in rodent models, there is a clear need for improved splinting techniques to increase surgical efficiency and support routine wound monitoring. Splinted wound healing models humanize wound healing in rodents to prevent contraction and instead heal through granulation tissue deposition, increasing the relevance to human wound healing. Current technologies require suturing and heavy wrapping, leading to splint failure and cumbersome monitoring of the wound.
View Article and Find Full Text PDFUpscaling from bench scale systems to field scale systems incorporates physical and chemical heterogeneities from atomistic up to field scales. Heterogeneities of intermediate scale (~10(-1) m) are impossible to incorporate in a bench scale experiment. To transcend these scale discrepancies, this second in a pair of papers presents results from an intermediate scale, 3-D tank experiment completed using five different particle sizes of uranium contaminated sediment from a former uranium mill field site.
View Article and Find Full Text PDFIntermediate scale tank studies were conducted to examine the effects of physical heterogeneity of aquifer material on uranium desorption and subsequent transport in order to bridge the scaling gap between bench and field scale systems. Uranium contaminated sediment from a former uranium mill field site was packed into two 2-D tanks with internal dimensions of 2.44×1.
View Article and Find Full Text PDFEnviron Sci Technol
February 2012
Given the unique properties of clays (i.e., low permeability and high ion sorption/exchange capacity), clays or clay formations have been proposed either as an engineered material or as a geologic medium for nuclear waste isolation and disposal.
View Article and Find Full Text PDFModels are a mainstay of the environmental sciences; they allow for both deeper understanding of process knowledge and, to a limited extent, predictive capabilities of current day inputs on the future. Mathematical codes have become increasingly complex with explicit inclusion of many processes that could not be accounted for using simpler solving techniques. And yet, for metal/radionuclide transport in subsurface systems, the inclusion of smaller scale processes in a numerical solver do not always lead to better descriptions of larger scale behavior.
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