The relationship between longevity and diet is genotype dependent and sensitive to desiccation in .

Dietary restriction (DR) is a key focus in ageing research. Specific conditions and genotypes were recently found to negate lifespan extension by DR, questioning its universal relevance. However, the concept of dietary reaction norms explains why the effects of DR might be obscured in some situations.

The hidden costs of dietary restriction: Implications for its evolutionary and mechanistic origins.

Dietary restriction (DR) extends life span across taxa. Despite considerable research, universal mechanisms of DR have not been identified, limiting its translational potential. Guided by the conviction that DR evolved as an adaptive, pro-longevity physiological response to food scarcity, biomedical science has interpreted DR as an activator of pro-longevity molecular pathways.

How to Catch a Smurf? - Ageing and Beyond… Assessment of Intestinal Permeability in Multiple Model Organisms.

The Smurf Assay (SA) was initially developed in the model organism where a dramatic increase of intestinal permeability has been shown to occur during aging (Rera , 2011). We have since validated the protocol in multiple other model organisms (Dambroise , 2016) and have utilized the assay to further our understanding of aging (Tricoire and Rera, 2015; Rera , 2018). The SA has now also been used by other labs to assess intestinal barrier permeability (Clark , 2015; Katzenberger , 2015; Barekat , 2016; Chakrabarti , 2016; Gelino , 2016).