CT perfusion for determination of pharmacologically mediated blood flow changes in an animal tumor model.

Purpose: To prospectively compare single- and multisection computed tomographic (CT) perfusion for tumor blood flow determination in an animal model.

Materials And Methods: All animal protocols and experiments were approved by the institutional animal care and use committee before the study was initiated. R3230 mammary adenocarcinoma was implanted in 11 rats.

High-power generator for radiofrequency ablation: larger electrodes and pulsing algorithms in bovine ex vivo and porcine in vivo settings.

Purpose: To prospectively maximize the extent of tissue coagulation by using a high-power (1000-W, 4000-mA) radiofrequency (RF) generator to optimize pulsing algorithms.

Materials And Methods: The institutional animal care and use committee approved the use of the animal model in the in vivo portion of this study. RF ablations (n = 258) were performed in ex vivo bovine livers by using a 500-kHz high-power generator.

Microwave ablation: results with a 2.45-GHz applicator in ex vivo bovine and in vivo porcine liver.

Purpose: To characterize the relationship between applied power and treatment duration in their effect on extent of coagulation produced with a 2.45-GHz microwave applicator in both an ex vivo and a perfused in vivo liver model.

Materials And Methods: All experimentation was approved by the Institute of Animal Care and Use Committee.

Radiofrequency ablation: importance of background tissue electrical conductivity--an agar phantom and computer modeling study.

Purpose: To determine whether radiofrequency (RF)-induced heating can be correlated with background electrical conductivity in a controlled experimental phantom environment mimicking different background tissue electrical conductivities and to determine the potential electrical and physical basis for such a correlation by using computer modeling.

Materials And Methods: The effect of background tissue electrical conductivity on RF-induced heating was studied in a controlled system of 80 two-compartment agar phantoms (with inner wells of 0.3%, 1.

Radiofrequency tumor ablation: insight into improved efficacy using computer modeling.

Objective: To use computer modeling of the Bio-Heat equation to demonstrate factors influencing RF ablation tissue heating.

Conclusion: Computer modeling demonstrates the importance of energy deposition, tumor and background tissue electrical and thermal conductivity, and perfusion on RF ablation outcomes.