Publications by authors named "Andrew Tobey"
A low-iodine diet (LID) of <50μ iodine/day is recommended as preparation for radioactive iodine (RAI) therapy in patients with differentiated thyroid cancer (DTC). The 24-h urinary iodine excretion (UIE) is utilized to evaluate the iodine-depleted status. The aim of this study was to test the association between UIE and progression-free survival (PFS).
View Article and Find Full Text PDFEpidemiological data reveal that treatment with lithium, a mood stabilizer, is associated with decreased incidence and mortality of certain cancer types, such as melanoma. Therefore, repositioning of lithium as an anticancer agent has emerged as a promising strategy in oncology. Since lithium affects the physiology of several endocrine tissues, the goal of this study was to analyze the role of lithium in the pathogenesis and treatment of tumors of the endocrine system.
View Article and Find Full Text PDFAnalysis of plasma circulating cell-free DNA integrity (cfDI) has emerged as a promising tool in the diagnosis of malignant vs. benign tumors. There is limited data on the role of cfDI in thyroid cancer.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to evaluate the effectiveness of three preparation methods for radioactive iodine therapy in patients with metastatic differentiated thyroid cancer: thyroid hormone withdrawal (THW), THW with lithium pretreatment (THW+Li), and recombinant human TSH (rhTSH).
- - Over a median follow-up of 5.1 years, the THW+Li group showed the longest overall survival (OS), but factors like older age and widespread disease significantly influenced survival outcomes, while no differences were observed in progression-free survival (PFS) between the groups.
- - The findings suggest that older age and the extent of disease impact OS and PFS in metastatic thyroid cancer, while the method of preparation for radioactive iodine therapy does not significantly