The effect of statins on muscle symptoms in primary care: the StatinWISE series of 200 N-of-1 RCTs.

Background: Uncertainty persists about whether or not statins cause symptomatic muscle adverse effects (e.g. pain, stiffness and weakness) in the absence of severe myositis.

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials.

Objective: To establish the effect of statins on muscle symptoms in people who had previously reported muscle symptoms when taking statins.

Design: Series of randomised, placebo controlled n-of-1 trials.

Setting: Primary care across 50 sites in the United Kingdom, December 2016 to April 2018.

Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial.

Background: Intravenous tranexamic acid (TXA) reduces bleeding deaths after injury and childbirth. It is most effective when given early. In many countries, pre-hospital care is provided by people who cannot give i.