Publications by authors named "Andrew T Yackzan"
Apolipoprotein ε4 (APOE4) carriers develop brain metabolic dysfunctions decades before the onset of Alzheimer's disease (AD). A goal of the study is to identify if rapamycin, an inhibitor for the mammalian target of rapamycin (mTOR) inhibitor, would enhance synaptic and mitochondrial function in asymptomatic mice with human APOE4 gene (E4FAD) before they showed metabolic deficits. A second goal is to determine whether there may be genetic-dependent responses to rapamycin when compared to mice with human APOE3 alleles (E3FAD), a neutral AD genetic risk factor.
View Article and Find Full Text PDFAccumulating evidence suggests that gut microbes modulate brain plasticity the bidirectional gut-brain axis and play a role in stroke rehabilitation. However, the microbial species alterations associated with stroke and their correlation with functional outcome measures following acute stroke remain unknown. Here we measure post-stroke gut dysbiosis and how it correlates with gut permeability and cognitive functions in 12 stroke participants, 18 controls with risk factors for stroke, and 12 controls without risk factors.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate how inulin, a prebiotic fiber, affects the metabolism and brain health in mice with different human APOE genetic variants (ϵ3 and ϵ4).
- Young mice were fed either inulin or a control diet for 16 weeks, and various analyses were performed to assess gut microbiome diversity, metabolic changes, and blood-brain barrier integrity.
- Results showed that inulin positively influenced gut bacteria and metabolites in both mouse types, but led to different metabolic changes in ϵ3 vs. ϵ4 mice, indicating that their genetic backgrounds could affect how nutrients are processed and their potential neuroprotective effects.