Re-evaluating the structure of consciousness through the symintentry hypothesis.

The Projective Consciousness Model and its extension to the phenomenal selfhood model are the generic invariant structures of consciousness through five symmetries. They include the following: situated 3D spatiality; temporal integration through encompassing the three "nows" that constitute the Now; multimodal synchronic integration; relational phenomenal intentionality; and consciousness entails a pre-reflective awareness of the uniqueness of the phenomenal self. These symmetries stem from the evolution and emergence of the phenomenal self through modeling, and that is realized through the phenomenal modeling of the intentionality relationship.

Management of the Airway in Apert Syndrome.

The management of the airway in Apert syndrome is complex and multidisciplinary. This rare syndrome, occurring in up to approximately 1 in 65,000 live births, results in airway compromise at various anatomic levels, in addition to abnormal central respiratory drive. Obstructive apneas arise because of decreased airway caliber, which may occur in the form of congenital bony nasal stenosis, choanal atresia, a deviated nasal septum, a narrowed nasopharynx, a thick long soft palate, lateral palatal swellings, and a tracheal cartilage sleeve.

Observational infant exploratory [(14)C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis.

Aims: The aims of the study were to compare [(14)C]-paracetamol ([(14)C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age group.

Methods: [(14)C]-PARA concentrations in 10-15 µl plasma samples were measured after enteral or i.v.

A novel presentation of inappropriate antidiuretic hormone secretion in Leigh syndrome with the myoclonic epilepsy and ragged red fibers, mitochondrial DNA 8344A>G mutation.

A 17-month-old infant presented with a 2-week history of lethargy, anorexia, and an abnormal respiratory pattern on a previous 4-month history of hypotonia and gross motor delay, suggesting a clinical phenotype of Leigh syndrome. The patient experienced no epileptic seizures. Biochemical investigations were normal other than showing evidence of inappropriate secretion of antidiuretic hormone, and cerebral magnetic resonance imaging (MRI) showed symmetrical lesions in the cervical cord and lower brain stem.

Genitourinary malformations as a feature of the Pallister-Hall syndrome.

Pallister-Hall and McKusick-Kaufman syndromes are developmental disorders with well defined phenotypes, distinct loci and different patterns of inheritance. The clinical features can overlap and may cause diagnostic difficulty, particularly if complex genitourinary malformations are present. A case is presented with features of both syndromes but in which a GLI3 mutation has been identified.

Novel use of skin substitute as rescue therapy in complicated giant exomphalos.

Giant exomphalos can be successfully managed using conservative or surgical techniques. However, if treatment is complicated by sepsis, early skin cover of the defect becomes necessary. Options include split skin grafting, but in the presence of ongoing infection the risk of graft failure is high and limited skin is available for regrafting.

Differences in resting energy expenditure between male and female children with cystic fibrosis.

Objectives: To evaluate which factors might contribute to raised resting energy expenditure (REE) in patients with cystic fibrosis (CF).

Study Design: REE and anthropometry were measured in 134 (males = 68) children with CF and 100 (males = 51) controls (range, 3-18.7 years) in an outpatient setting.

Differing pathways of lower airway colonization and infection according to mode of ventilation (endotracheal vs tracheotomy).

Objectives: To determine whether the pathogenesis of lower airway colonization and infection was endogenous (via the oropharynx) or exogenous (via the endotracheal tube or tracheotomy) during the 2 modes of ventilation in the same subset of children requiring long-term ventilation.

Design: Prospective, observational cohort study.

Setting: A pediatric intensive care unit and a respiratory ward.

Assessment of adrenal function in the initial phase of meningococcal disease.

Objective: To determine the status of the hypothalamic-pituitary-adrenal axis in children who had meningococcal disease and were admitted to 2 regional pediatric intensive care units.

Methods: Sixty-five children (34 boys; median age: 2.5 years; range: 0.