Publications by authors named "Andrew S T Lim"
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integrating whole cell screening and metabolomics into early antibacterial drug discovery using a library of small polar compounds.
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- ATRA is important for the development of epithelial and neural tissues, sparking interest in its use for treating various diseases, including cancer and neurodegenerative disorders.
- The clinical application of ATRA is limited by its short half-life in the body, due to specific enzymes inactivating it, leading to the creation of retinoic acid metabolism blocking agents (RAMBAs) for enhanced efficacy.
- Research on new compounds has shown that specific structural modifications can enhance their ability to inhibit CYP26A1 enzyme activity, with compounds like methylenedioxyphenyl imidazole and triazole exhibiting strong inhibitory effects.