Publications by authors named "Andrew R Nimmich"
Adv Biosci Biotechnol
August 2013
Article Synopsis
- Hemorrhagic cystitis (HC) is a common issue for patients undergoing cyclophosphamide (CP) chemotherapy, even with 2-mercaptothane sulfonate (Mesna) treatment to reduce the harmful effects of acrolein.
- A study examined apoptosis (cell death) in the bladder tissue (urothelium) post-CP treatment, identifying two distinct waves of apoptosis at 2 hours and 48 hours after administration.
- The first wave of apoptosis occurs independent of acrolein and involves caspase-1's direct activation of caspase-3/7, highlighting a mechanism of damage separate from acrolein's effects.
