Publications by authors named "Andrew O Chukwuemeka"
Article Synopsis
- Transcatheter aortic valve replacement (TAVR) is a recognized treatment for severe aortic stenosis and has recently been applied to treat failures of bioprosthetic surgical aortic valves (sAVR) through a technique known as valve-in-valve TAVR (ViV-TAVR).
- Though data on ViV-TAVR primarily come from observational studies, initial findings suggest it offers similar outcomes to re-do sAVR in high-risk patients.
- The case presented in this text highlights a rare situation of TAVR failure in a patient who had prior sAVR, necessitating an innovative procedure called valve-in-valve-in-valve TAVR (ViViV-TAVR).
Background: During cardiac surgery involving cardiopulmonary bypass, activation of polymorphonuclear cells is believed to contribute to ischemia-reperfusion injury and subsequent myocardial impairment of function. The early tethering of polymorphonuclear cells to blood vessel walls depends upon recognition of the adhesion molecule P-selectin on endothelium. The purpose of this study was to define the kinetic changes in expression of P-selectin on myocardial vessels in a model of global ischemia-reperfusion injury.
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