Publications by authors named "Andrew N Hakeem"
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks an actionable target with limited treatment options beyond conventional chemotherapy. Therapeutic failure is often encountered due to inherent or acquired resistance to chemotherapy. Previous studies implicated PI3K/Akt/mTOR signaling pathway in cancer stem cells (CSCs) enrichment and hence chemoresistance.
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- Disrupted gut barrier integrity is linked to the immune response in non-alcoholic steatohepatitis (NASH), particularly affecting macrophages that contribute to its progression.* -
- The study investigates the effects of elafibranor (ELA), a dual PPAR α/δ agonist, on macrophage polarization and liver health in a NASH context, using both in vitro models and a dietary NASH with chronic colitis model.* -
- Results show that ELA reduces fat accumulation in the liver, improves intestinal barrier function by enhancing tight junction proteins, and soothes inflammation by shifting macrophages towards a protective M2 phenotype, which may help alleviate NASH.*